Abstract
Poikiloderma vasculare atrophicans (PVA) is a rare poikilodermatous variant of early-stage mycosis fungoides characterized by generalized poikiloderma, atrophy, mottled dyspigmentation, and telangiectasia. In 2001, a 14-year-old male presented with asymptomatic brownish-gray polymorphic macules throughout the body with flexural accentuation. A skin biopsy showed increased melanophages with focal hydropic changes. Ashy dermatosis was considered a possible diagnosis. In 2005, the lesions began to show darkening and lichenification in the lower part of the trunk. In 2011, his skin showed definite poikilodermatous changes, and a biopsy showed band-like inflammatory infiltrations of atypical lymphocytes, epidermal atrophy, and epidermotropism of predominantly CD4-CD8+ atypical T cells. In addition, results of T-cell receptor gene rearrangement analysis were positive. Based on the aforementioned findings, he was diagnosed with PVA. If a patient shows long-standing and progressive hyperpigmentary skin changes, periodic follow- up and repeated skin biopsies are recommended to determine the underlying condition. (Ann Dermatol 27(2) 197∼ 200, 2015).
Original language | English |
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Pages (from-to) | 197-200 |
Number of pages | 4 |
Journal | Annals of Dermatology |
Volume | 27 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2015 Apr 1 |
Externally published | Yes |
Keywords
- CD4
- CD4-CD8 ratio
- CD8
- Mycosis fungoides
- Poikiloderma
- T-lymphocytes
ASJC Scopus subject areas
- Dermatology