Polarity probing two-photon fluorophores based on [2.2]paracyclophane

Young Woo Han, Dmitry Korystov, Youngeup Jin, Hongsuk Suh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A series of tetra donor substituted [2.2]paracyclophane-based two-photon absorption (TPA) fluorophores were synthesized in neutral and cationic forms. The imaging activity of overall set of fluorophores was studied by the two-photon induced fluorescence (TPIF) method in a range of solvents. We also measured a clear progression toward a longer photoluminescence lifetime with increasing solvent polarity (intrinsic photoluminescence lifetime, πi: ∼2 ns in toluene → 12-16 ns in water). The paracyclophane fluorophores with this unique property can be utilized as an optical polarity probe for the biomolecular substrates. The combined measurement of the two-photon fluorescence microscopy (TPM) cell image and TPIF lifetime can give us a better understanding of the biological processes and local environments in the cells.

Original languageEnglish
Pages (from-to)2253-2260
Number of pages8
JournalBulletin of the Korean Chemical Society
Issue number12
Publication statusPublished - 2007 Dec 20
Externally publishedYes


  • Bioimaging
  • Fluorescent label
  • Paracyclophane
  • Two-photon absorption
  • Two-photon fluorophore

ASJC Scopus subject areas

  • Chemistry(all)


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