Polarity probing two-photon fluorophores based on [2.2]paracyclophane

Young Woo Han; Dmitry Korystov; Youngeup Jin; Hongsuk Suh

doi:10.5012/bkcs.2007.28.12.2253

Polarity probing two-photon fluorophores based on [2.2]paracyclophane

Young Woo Han, Dmitry Korystov, Youngeup Jin, Hongsuk Suh

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A series of tetra donor substituted [2.2]paracyclophane-based two-photon absorption (TPA) fluorophores were synthesized in neutral and cationic forms. The imaging activity of overall set of fluorophores was studied by the two-photon induced fluorescence (TPIF) method in a range of solvents. We also measured a clear progression toward a longer photoluminescence lifetime with increasing solvent polarity (intrinsic photoluminescence lifetime, π_i: ∼2 ns in toluene → 12-16 ns in water). The paracyclophane fluorophores with this unique property can be utilized as an optical polarity probe for the biomolecular substrates. The combined measurement of the two-photon fluorescence microscopy (TPM) cell image and TPIF lifetime can give us a better understanding of the biological processes and local environments in the cells.

Original language	English
Pages (from-to)	2253-2260
Number of pages	8
Journal	Bulletin of the Korean Chemical Society
Volume	28
Issue number	12
DOIs	https://doi.org/10.5012/bkcs.2007.28.12.2253
Publication status	Published - 2007 Dec 20
Externally published	Yes

Keywords

Bioimaging
Fluorescent label
Paracyclophane
Two-photon absorption
Two-photon fluorophore

ASJC Scopus subject areas

Chemistry(all)

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10.5012/bkcs.2007.28.12.2253

Cite this

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abstract = "A series of tetra donor substituted [2.2]paracyclophane-based two-photon absorption (TPA) fluorophores were synthesized in neutral and cationic forms. The imaging activity of overall set of fluorophores was studied by the two-photon induced fluorescence (TPIF) method in a range of solvents. We also measured a clear progression toward a longer photoluminescence lifetime with increasing solvent polarity (intrinsic photoluminescence lifetime, πi: ∼2 ns in toluene → 12-16 ns in water). The paracyclophane fluorophores with this unique property can be utilized as an optical polarity probe for the biomolecular substrates. The combined measurement of the two-photon fluorescence microscopy (TPM) cell image and TPIF lifetime can give us a better understanding of the biological processes and local environments in the cells.",

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AU - Han, Young Woo

AU - Korystov, Dmitry

AU - Jin, Youngeup

AU - Suh, Hongsuk

PY - 2007/12/20

Y1 - 2007/12/20

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AB - A series of tetra donor substituted [2.2]paracyclophane-based two-photon absorption (TPA) fluorophores were synthesized in neutral and cationic forms. The imaging activity of overall set of fluorophores was studied by the two-photon induced fluorescence (TPIF) method in a range of solvents. We also measured a clear progression toward a longer photoluminescence lifetime with increasing solvent polarity (intrinsic photoluminescence lifetime, πi: ∼2 ns in toluene → 12-16 ns in water). The paracyclophane fluorophores with this unique property can be utilized as an optical polarity probe for the biomolecular substrates. The combined measurement of the two-photon fluorescence microscopy (TPM) cell image and TPIF lifetime can give us a better understanding of the biological processes and local environments in the cells.

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KW - Fluorescent label

KW - Paracyclophane

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KW - Two-photon fluorophore

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Polarity probing two-photon fluorophores based on [2.2]paracyclophane

Abstract

Keywords

ASJC Scopus subject areas

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