Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Ran Namgung; Yeong Mi Lee; Jihoon Kim; Yuna Jang; Byung Heon Lee; In San Kim; Pandian Sokkar; Young Min Rhee; Allan S. Hoffman; Won Jong Kim

doi:10.1038/ncomms4702

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Ran Namgung, Yeong Mi Lee, Jihoon Kim, Yuna Jang, Byung Heon Lee, In San Kim, Pandian Sokkar, Young Min Rhee, Allan S. Hoffman, Won Jong Kim

Research output: Contribution to journal › Article › peer-review

194 Citations (Scopus)

Abstract

Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.

Original language	English
Article number	3702
Journal	Nature communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms4702
Publication status	Published - 2014 May 8
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by the Research Center Program of IBS (Institute for Basic Science) in Korea (CA1203-02) and a grant NRF-2012M2A2A7035589 through the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST).

ASJC Scopus subject areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ncomms4702

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title = "Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy",

abstract = "Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.",

author = "Ran Namgung and {Mi Lee}, Yeong and Jihoon Kim and Yuna Jang and Lee, {Byung Heon} and Kim, {In San} and Pandian Sokkar and Rhee, {Young Min} and Hoffman, {Allan S.} and Kim, {Won Jong}",

note = "Funding Information: This research was supported by the Research Center Program of IBS (Institute for Basic Science) in Korea (CA1203-02) and a grant NRF-2012M2A2A7035589 through the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST).",

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AU - Namgung, Ran

AU - Mi Lee, Yeong

AU - Kim, Jihoon

AU - Jang, Yuna

AU - Lee, Byung Heon

AU - Kim, In San

AU - Sokkar, Pandian

AU - Rhee, Young Min

AU - Hoffman, Allan S.

AU - Kim, Won Jong

N1 - Funding Information: This research was supported by the Research Center Program of IBS (Institute for Basic Science) in Korea (CA1203-02) and a grant NRF-2012M2A2A7035589 through the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST).

PY - 2014/5/8

Y1 - 2014/5/8

N2 - Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.

AB - Effective anticancer therapy can be achieved by designing a targeted drug-delivery system with high stability during circulation and efficient uptake by the target tumour cancer cells. We report here a novel nano-assembled drug-delivery system, formed by multivalent host-guest interactions between a polymer-cyclodextrin conjugate and a polymer-paclitaxel conjugate. The multivalent inclusion complexes confer high stability to the nano-assembly, which efficiently delivers paclitaxel into the targeted cancer cells via both passive and active targeting mechanisms. The ester linkages between paclitaxel and the polymer backbone permit efficient release of paclitaxel within the cell by degradation. This novel targeted nano-assembly exhibits significant antitumour activity in a mouse tumour model. The strategy established in this study also provides knowledge for the development of advanced anticancer drug delivery.

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Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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