Polyacetylenes from the roots of Cirsium japonicum var. ussuriense

Seung Hyun Lee, Jun Gu Kim, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Mi Kyeong Lee, Dongho Lee, Bang Yeon Hwang

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Eight previously undescribed polyacetylenes, cirussurynes A-H, were isolated from the methanolic extract of the roots of Cirsium japonicum var. ussuriense. Their structures were elucidated by interpretation of extensive 1D and 2D NMR spectroscopy and HRESIMS spectrometry data. The configuration of triols in cirussurynes A, B, and E-G was deduced by the J-value based configuration analysis together with specific rotation values. All compounds were evaluated for their inhibitory effects on nitric oxide production against LPS-induced RAW 264.7 macrophages, and exhibited IC50 values ranging from 5.5 to 68.7 μM.

    Original languageEnglish
    Article number113319
    JournalPhytochemistry
    Volume202
    DOIs
    Publication statusPublished - 2022 Oct

    Bibliographical note

    Funding Information:
    This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MIST) (No. 2020R1A2C1008406). The authors wish to thank the Korea Basic Science Institute for the NMR spectroscopic measurements.

    Funding Information:
    This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government ( MIST ) (No. 2020R1A2C1008406 ). The authors wish to thank the Korea Basic Science Institute for the NMR spectroscopic measurements.

    Publisher Copyright:
    © 2022 Elsevier Ltd

    Keywords

    • Asteraceae
    • Cirsium japonicum var. ussuriense
    • Nitric oxide
    • Polyacetylene
    • Structure elucidation

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Plant Science
    • Horticulture

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