Polyacetylenes from the roots of Cirsium japonicum var. ussuriense

Seung Hyun Lee, Jun Gu Kim, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Mi Kyeong Lee, Dongho Lee, Bang Yeon Hwang

Research output: Contribution to journalArticlepeer-review


Eight previously undescribed polyacetylenes, cirussurynes A-H, were isolated from the methanolic extract of the roots of Cirsium japonicum var. ussuriense. Their structures were elucidated by interpretation of extensive 1D and 2D NMR spectroscopy and HRESIMS spectrometry data. The configuration of triols in cirussurynes A, B, and E-G was deduced by the J-value based configuration analysis together with specific rotation values. All compounds were evaluated for their inhibitory effects on nitric oxide production against LPS-induced RAW 264.7 macrophages, and exhibited IC50 values ranging from 5.5 to 68.7 μM.

Original languageEnglish
Article number113319
Publication statusPublished - 2022 Oct


  • Asteraceae
  • Cirsium japonicum var. ussuriense
  • Nitric oxide
  • Polyacetylene
  • Structure elucidation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture


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