Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Sae Rom Choi; Dong Jin Jang; Sanghyun Kim; Sunhyung An; Jinwoo Lee; Euichaul Oh; Jungbae Kim

doi:10.1039/c3tb21494j

Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Sae Rom Choi, Dong Jin Jang, Sanghyun Kim, Sunhyung An, Jinwoo Lee, Euichaul Oh, Jungbae Kim

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this system behaves under different pH conditions.

Original language	English
Pages (from-to)	616-619
Number of pages	4
Journal	Journal of Materials Chemistry B
Volume	2
Issue number	6
DOIs	https://doi.org/10.1039/c3tb21494j
Publication status	Published - 2014 Feb 14

ASJC Scopus subject areas

General Chemistry
Biomedical Engineering
General Materials Science

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10.1039/c3tb21494j

Cite this

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abstract = "We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this system behaves under different pH conditions.",

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AU - Choi, Sae Rom

AU - Jang, Dong Jin

AU - Kim, Sanghyun

AU - An, Sunhyung

AU - Lee, Jinwoo

AU - Oh, Euichaul

AU - Kim, Jungbae

PY - 2014/2/14

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N2 - We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this system behaves under different pH conditions.

AB - We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this system behaves under different pH conditions.

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Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Abstract

ASJC Scopus subject areas

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