Abstract
Nanomedicine, an offshoot of nanotechnology, refers to highly specific, molecular-scale medical intervention for treating disease or repairing damaged tissues. In recent years, polymer-based nanomedicine, a field that includes the use of polymer-DNA complexes (polyplexes), polymer-drug conjugates, and polymer micelles bearing hydrophobic drugs, has received increasing attention for its ability to improve the efficacy of cancer therapeutics. Owing to their small size and excellent biocompatibility, nanosized polymer therapeutic agents can circulate in the bloodstream for long periods of time, allowing them to reach the target site. In addition, chemical modification of polymer therapeutic agents with ligands capable of specifically binding receptors that are over-expressed in cancer cells can markedly augment therapeutic efficiency. This review highlights the characteristics of cancer that provide nanodrug targeting opportunities and discusses rational approaches for future development of polymeric nanomedicines.
| Original language | English |
|---|---|
| Pages (from-to) | 113-137 |
| Number of pages | 25 |
| Journal | Progress in Polymer Science (Oxford) |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2008 Jan |
| Externally published | Yes |
Bibliographical note
Funding Information:This research was supported by the KIST intramural “Molecular Imaging Research Project” and by a Grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A062254B8150506N11C011B).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
Keywords
- Angiogenesis
- Cancer therapy
- Drug carrier
- Polymeric nanomedicine
- Targeted delivery
ASJC Scopus subject areas
- Ceramics and Composites
- Surfaces and Interfaces
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry
