Polymeric nanoparticle-based activatable near-infrared nanosensor for protease determination in vivo

Seulki Lee, Ju Hee Ryu, Kyeongsoon Park, Aeju Lee, Seung Young Lee, In Chan Youn, Cheol Hee Ahn, Soon Man Yoon, Seung Jae Myung, Dae Hyuk Moon, Xiaoyuan Chen, Kuiwon Choi, Ick Chan Kwon, Kwangmeyung Kim

    Research output: Contribution to journalArticlepeer-review

    140 Citations (Scopus)

    Abstract

    We report here a new protease activatable strategy based on a polymer nanoparticle platform. This nanosensor delivers chemically labeled matrix metalloproteinase (MMP)-activatable fluorogenic peptides to the specific MMPs of interest in vivo. Intravenous administration of the nanosensor in an MMP-positive SCC-7 xenograft tumor and a colon cancer mouse model verified the enzyme specificity of the nanosensor in vivo. The design platform of the nanosensor is flexible and can be fine-tuned for a wide array of applications such as the detection of biomarkers, early diagnosis of disease, and monitoring therapeutic efficacy.

    Original languageEnglish
    Pages (from-to)4412-4416
    Number of pages5
    JournalNano Letters
    Volume9
    Issue number12
    DOIs
    Publication statusPublished - 2009 Dec 9

    ASJC Scopus subject areas

    • Bioengineering
    • General Chemistry
    • General Materials Science
    • Condensed Matter Physics
    • Mechanical Engineering

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