TY - JOUR
T1 - Porohyperelastic anatomical models for hydrocephalus and idiopathic intracranial hypertension
AU - Kim, Hakseung
AU - Min, Byoung-Kyong
AU - Park, Dae Hyeon
AU - Hawi, Stanley
AU - Kim, Byung Jo
AU - Czosnyka, Zofia
AU - Czosnyka, Marek
AU - Sutcliffe, Michael P F
AU - Kim, Dong Ju
N1 - Publisher Copyright:
© AANS, 2015.
PY - 2015/6
Y1 - 2015/6
N2 - OBJECT: Brain deformation can be seen in hydrocephalus and idiopathic intracranial hypertension (IIH) via medical images. The phenomenology of local effects, brain shift, and raised intracranial pressure and herniation are textbook concepts. However, there are still uncertainties regarding the specific processes that occur when brain tissue is subject to the mechanical stress of different temporal and spatial profiles of the 2 neurological disorders. Moreover, recent studies suggest that IIH and hydrocephalus may be diseases with opposite pathogenesis. Nevertheless, the similarities and differences between the 2 subjects have not been thoroughly investigated. METHODS: An anatomical porohyperelastic finite element model was used to assess the brain tissue responses associated with hydrocephalus and IIH. The same set of boundary conditions, with the exception of brain loading for development of the transmantle pressure gradient, was applied for the 2 models. The distribution of stress and strain during tissue distortion is described by the mechanical parameters. RESULTS: The RESULTS: of both the hydrocephalus and IIH models correlated with pathological characteristics. For the hydrocephalus model, periventricular edema was associated with the presence of positive volumetric strain and void ratio in the lateral ventricle horns. By contrast, the IIH model revealed edema across the cerebral mantle, including the centrum semiovale, with a positive void ratio and volumetric strain. CONCLUSIONS: The model simulates all the clinical features in correlation with the MR images obtained in patients with hydrocephalus and IIH, thus providing support for the role of the transmantle pressure gradient and capillary CSF absorption in CSF-related brain deformation. The finite element METHODS: can be used for a better understanding of the pathophysiological mechanisms of neurological disorders associated with parenchymal volumetric fiuctuation.
AB - OBJECT: Brain deformation can be seen in hydrocephalus and idiopathic intracranial hypertension (IIH) via medical images. The phenomenology of local effects, brain shift, and raised intracranial pressure and herniation are textbook concepts. However, there are still uncertainties regarding the specific processes that occur when brain tissue is subject to the mechanical stress of different temporal and spatial profiles of the 2 neurological disorders. Moreover, recent studies suggest that IIH and hydrocephalus may be diseases with opposite pathogenesis. Nevertheless, the similarities and differences between the 2 subjects have not been thoroughly investigated. METHODS: An anatomical porohyperelastic finite element model was used to assess the brain tissue responses associated with hydrocephalus and IIH. The same set of boundary conditions, with the exception of brain loading for development of the transmantle pressure gradient, was applied for the 2 models. The distribution of stress and strain during tissue distortion is described by the mechanical parameters. RESULTS: The RESULTS: of both the hydrocephalus and IIH models correlated with pathological characteristics. For the hydrocephalus model, periventricular edema was associated with the presence of positive volumetric strain and void ratio in the lateral ventricle horns. By contrast, the IIH model revealed edema across the cerebral mantle, including the centrum semiovale, with a positive void ratio and volumetric strain. CONCLUSIONS: The model simulates all the clinical features in correlation with the MR images obtained in patients with hydrocephalus and IIH, thus providing support for the role of the transmantle pressure gradient and capillary CSF absorption in CSF-related brain deformation. The finite element METHODS: can be used for a better understanding of the pathophysiological mechanisms of neurological disorders associated with parenchymal volumetric fiuctuation.
KW - Bi-phase
KW - Biomechanics
KW - Cerebrospinal fluid
KW - Finite element model
KW - Hydrocephalus
KW - Idiopathic intracranial hypertension
UR - http://www.scopus.com/inward/record.url?scp=84938493360&partnerID=8YFLogxK
U2 - 10.3171/2014.12.JNS14516
DO - 10.3171/2014.12.JNS14516
M3 - Article
C2 - 25658783
AN - SCOPUS:84938493360
SN - 0022-3085
VL - 122
SP - 1330
EP - 1340
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
IS - 6
ER -