Abstract
The combination of microarray and microparticle technologies can result in synergistic effects for high-performance bioassays. Here, we present a porous microwell platform that is used to generate large-scale, ordered microparticle arrays. We guide particles to the microwells via hydrodynamic forces associated with fluid flow through open pores inside the microwell. After particles block the microwell perfectly, applied pressure deforms the microparticles to squeeze into the slightly smaller microwells. With this process, we demonstrated large-scale (10<sup>3</sup>-10<sup>4</sup>) particle assembly with high filling yield (94 %) and high assembling of initial particles (88 %). Sorting was based on size, modulus, and shape (specificity > 95 %).
| Original language | English |
|---|---|
| Title of host publication | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1763-1765 |
| Number of pages | 3 |
| ISBN (Print) | 9780979806476 |
| Publication status | Published - 2014 |
| Event | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: 2014 Oct 26 → 2014 Oct 30 |
Other
| Other | 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 |
|---|---|
| Country/Territory | United States |
| City | San Antonio |
| Period | 14/10/26 → 14/10/30 |
Keywords
- Large-scale array
- Microparticles
- Porous microwells
- Sorting
ASJC Scopus subject areas
- Control and Systems Engineering