Porous TiO2 films on Ti implants for controlled release of tetracycline-hydrochloride (TCH)

Cheol Min Han; Eun Jung Lee; Hyoun Ee Kim; Young Hag Koh; Jun Hyeog Jang

doi:10.1016/j.tsf.2011.06.013

Porous TiO₂ films on Ti implants for controlled release of tetracycline-hydrochloride (TCH)

Cheol Min Han, Eun Jung Lee, Hyoun Ee Kim, Young Hag Koh, Jun Hyeog Jang

School of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Micro- and nano-porous TiO₂ films were created on the surface of Ti implants using micro-arc oxidation and anodic titanium oxide treatments, respectively, to load a sol-gel derived silica xerogel for the controlled release of the antibiotic drug, tetracycline-hydrochloride (TCH). When the silica xerogel containing TCH was loaded into porous TiO₂ films, a very high drug loading efficiency was observed compared to when it was loaded in Ti implants without a TiO₂ film. Moreover, TCH was released in a controlled manner for up to 7 days.

Original language	English
Pages (from-to)	8074-8076
Number of pages	3
Journal	Thin Solid Films
Volume	519
Issue number	22
DOIs	https://doi.org/10.1016/j.tsf.2011.06.013
Publication status	Published - 2011 Sept 1

Keywords

Anodic titanium oxide
Controlled drug release
Micro-arc oxidation
Silica xerogel

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Surfaces and Interfaces
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1016/j.tsf.2011.06.013

Cite this

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title = "Porous TiO2 films on Ti implants for controlled release of tetracycline-hydrochloride (TCH)",

abstract = "Micro- and nano-porous TiO2 films were created on the surface of Ti implants using micro-arc oxidation and anodic titanium oxide treatments, respectively, to load a sol-gel derived silica xerogel for the controlled release of the antibiotic drug, tetracycline-hydrochloride (TCH). When the silica xerogel containing TCH was loaded into porous TiO2 films, a very high drug loading efficiency was observed compared to when it was loaded in Ti implants without a TiO2 film. Moreover, TCH was released in a controlled manner for up to 7 days.",

keywords = "Anodic titanium oxide, Controlled drug release, Micro-arc oxidation, Silica xerogel",

author = "Han, {Cheol Min} and Lee, {Eun Jung} and Kim, {Hyoun Ee} and Koh, {Young Hag} and Jang, {Jun Hyeog}",

note = "Funding Information: This research was supported by WCU (World Class University) project through National Research Foundation of Korea funded by the Ministry of Education, Science and Technology ( R31-2008-000-10075-0 ) and by the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea .",

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AU - Han, Cheol Min

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AU - Koh, Young Hag

AU - Jang, Jun Hyeog

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N2 - Micro- and nano-porous TiO2 films were created on the surface of Ti implants using micro-arc oxidation and anodic titanium oxide treatments, respectively, to load a sol-gel derived silica xerogel for the controlled release of the antibiotic drug, tetracycline-hydrochloride (TCH). When the silica xerogel containing TCH was loaded into porous TiO2 films, a very high drug loading efficiency was observed compared to when it was loaded in Ti implants without a TiO2 film. Moreover, TCH was released in a controlled manner for up to 7 days.

AB - Micro- and nano-porous TiO2 films were created on the surface of Ti implants using micro-arc oxidation and anodic titanium oxide treatments, respectively, to load a sol-gel derived silica xerogel for the controlled release of the antibiotic drug, tetracycline-hydrochloride (TCH). When the silica xerogel containing TCH was loaded into porous TiO2 films, a very high drug loading efficiency was observed compared to when it was loaded in Ti implants without a TiO2 film. Moreover, TCH was released in a controlled manner for up to 7 days.

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