Poststroke emotional disturbances and a tryptophan hydroxylase 2 gene polymorphism

Mihye Ko, Smi Choi-Kwon, Sang Eun Jun, Ju Han Kim, Kyung Hee Cho, Hyun Wook Nah, Hasup Song, Jong S. Kim

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)


    Objectives: Emotional dysfunction is a common finding in stroke patients. Despite reports on serotonergic involvement in the etiology of poststroke emotional dysfunction (PSED), the role of serotonin synthesizing tryptophan hydroxylase 2 (TPH2) genes in the development of PSED remains unclear. Methods: Genotyping of TPH2 rs4641528 and rs10879355 was performed from genomic DNA of 383 stroke patients collected previously and stored at −70°C. Potential associations between TPH2 genes and poststroke depression (PSD), poststroke emotional incontinence (PSEI), and poststroke anger proneness (PSAP) were investigated 3 months poststroke. Results: Among the 383 patients, 69 (18%) had PSD, 41 (11%) had PSEI, and 93 (24%) had PSAP. The TPH2 rs4641528 genotype frequencies differed significantly between patients with and without either PSD or PSEI, although no significant differences were found between the patients with and without PSAP. In multiple logistic regression analysis, PSD was related to the National Institutes of Health Stroke Scale (NIHSS) score at admission (95% confidence interval [CI]: 1.047–1.230, p <.01), modified Rankin scale score at 3 months (95% CI: 0.135–0.848, p <.05), and TPH2 rs4641528 C allele (95% CI: 1.039–5.631, p <.05), whereas PSEI was associated only with the NIHSS score at admission (95% CI: 1.053–1.259, p <.01) and the TPH2 rs4641528 C allele (95% CI: 1.029–11.678, p <.05). Conclusions: Our findings suggest that the TPH2 rs4641528 C allele may play a role in the pathogenesis of PSD and PSEI but not PSAP in Korean stroke patients.

    Original languageEnglish
    Article numbere00892
    JournalBrain and Behavior
    Issue number2
    Publication statusPublished - 2018 Feb

    Bibliographical note

    Funding Information:
    This study was supported by Korea Research Foundation (No.

    Funding Information:
    This study was supported by Korea Research Foundation (No. 810-20150019).

    Publisher Copyright:
    © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.


    • depression
    • emotional disturbances
    • gene
    • polymorphism
    • stroke
    • tryptophan hydroxylase

    ASJC Scopus subject areas

    • Behavioral Neuroscience


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