Potential roles of stem cell marker genes in axon regeneration

Jinyoung Lee, Yongcheol Cho

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Axon regeneration is orchestrated by many genes that are differentially expressed in response to injury. Through a comparative analysis of gene expression profiling, injury-responsive genes that are potential targets for understanding the mechanisms underlying regeneration have been revealed. As the efficiency of axon regeneration in both the peripheral and central nervous systems can be manipulated, we suggest that identifying regeneration-associated genes is a promising approach for developing therapeutic applications in vivo. Here, we review the possible roles of stem cell marker- or stemness-related genes in axon regeneration to gain a better understanding of the regeneration mechanism and to identify targets that can enhance regenerative capacity.

Original languageEnglish
JournalExperimental and Molecular Medicine
Volume53
Issue number1
DOIs
Publication statusPublished - 2021 Jan

Bibliographical note

Funding Information:
The authors thank Zehra Alibasic for critical reading the manuscript. This work was supported by the National Research Foundation of Korea funded by the Korean Ministry of Science, Information and Communication Technology and Future Planning (Grant 2015R1A5A1009024 to Y.C.).

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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