Abstract
Many clinical trials have shown the effectiveness of platelet releasate on diabetic wound healing, but large volumes of blood must be aspirated from patients and a platelet separator is required. This study was undertaken to investigate the potential of blood bank platelet concentrate (BBPC) for accelerating diabetic wound healing. Platelet-derived growth factor-BB (PDGF-BB) contents in BBPC were determined by enzyme-linked immunosorbent assay in vitro, and the in vivo study involved comparing extents of wound healing in BBPC-treated and control groups using diabetic mouse wound models. In the in vitro study, 5.2 ± 1.2 pg of PDGF-BB was found to be released by 1 million platelets in fresh BBPC, and adding thrombin to BBPC significantly increased the levels of PDGF-BB released. Our in vivo study in diabetic mice revealed that BBPC treatment greatly accelerated wound healing. Our results suggest that BBPC has potential to accelerate the healing of diabetic ulcers.
| Original language | English |
|---|---|
| Pages (from-to) | 532-537 |
| Number of pages | 6 |
| Journal | Annals of Plastic Surgery |
| Volume | 59 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2007 Nov |
Keywords
- Blood bank platelet concentrate
- Diabetic ulcer
- Wound healing
ASJC Scopus subject areas
- Surgery
