Prdm4 induction by the small molecule butein promotes white adipose tissue browning

No Joon Song; Seri Choi; Prashant Rajbhandari; Seo Hyuk Chang; Suji Kim; Laurent Vergnes; So Mi Kwon; Jung Hoon Yoon; Sukchan Lee; Jin Mo Ku; Jeong Soo Lee; Karen Reue; Seung Hoi Koo; Peter Tontonoz; Kye Won Park

doi:10.1038/nchembio.2081

Prdm4 induction by the small molecule butein promotes white adipose tissue browning

No Joon Song, Seri Choi, Prashant Rajbhandari, Seo Hyuk Chang, Suji Kim, Laurent Vergnes, So Mi Kwon, Jung Hoon Yoon, Sukchan Lee, Jin Mo Ku, Jeong Soo Lee, Karen Reue, Seung Hoi Koo, Peter Tontonoz, Kye Won Park

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

Original language	English
Pages (from-to)	479-481
Number of pages	3
Journal	Nature Chemical Biology
Volume	12
Issue number	7
DOIs	https://doi.org/10.1038/nchembio.2081
Publication status	Published - 2016 Jul 1

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (NRF-2013R1A1A2060447 to K.W.P.), and by the KRIBB Research Initiative Program (J.-S.L.). This study was also supported by the US National Institutes of Health (HL090553 to K.R. and F32 DK104484-01 to P.R.).

Publisher Copyright:
© 2016 Nature America, Inc. All rights reserved.

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Prdm4 induction by the small molecule butein promotes white adipose tissue browning",

abstract = "Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.",

author = "Song, {No Joon} and Seri Choi and Prashant Rajbhandari and Chang, {Seo Hyuk} and Suji Kim and Laurent Vergnes and Kwon, {So Mi} and Yoon, {Jung Hoon} and Sukchan Lee and Ku, {Jin Mo} and Lee, {Jeong Soo} and Karen Reue and Koo, {Seung Hoi} and Peter Tontonoz and Park, {Kye Won}",

note = "Funding Information: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (NRF-2013R1A1A2060447 to K.W.P.), and by the KRIBB Research Initiative Program (J.-S.L.). This study was also supported by the US National Institutes of Health (HL090553 to K.R. and F32 DK104484-01 to P.R.). Publisher Copyright: {\textcopyright} 2016 Nature America, Inc. All rights reserved.",

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AU - Rajbhandari, Prashant

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AU - Kim, Suji

AU - Vergnes, Laurent

AU - Kwon, So Mi

AU - Yoon, Jung Hoon

AU - Lee, Sukchan

AU - Ku, Jin Mo

AU - Lee, Jeong Soo

AU - Reue, Karen

AU - Koo, Seung Hoi

AU - Tontonoz, Peter

AU - Park, Kye Won

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N2 - Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

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Prdm4 induction by the small molecule butein promotes white adipose tissue browning

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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