Prdm4 induction by the small molecule butein promotes white adipose tissue browning

No Joon Song, Seri Choi, Prashant Rajbhandari, Seo Hyuk Chang, Suji Kim, Laurent Vergnes, So Mi Kwon, Jung Hoon Yoon, Sukchan Lee, Jin Mo Ku, Jeong Soo Lee, Karen Reue, Seung Hoi Koo, Peter Tontonoz, Kye Won Park

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

Original languageEnglish
Pages (from-to)479-481
Number of pages3
JournalNature Chemical Biology
Issue number7
Publication statusPublished - 2016 Jul 1

Bibliographical note

Funding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (NRF-2013R1A1A2060447 to K.W.P.), and by the KRIBB Research Initiative Program (J.-S.L.). This study was also supported by the US National Institutes of Health (HL090553 to K.R. and F32 DK104484-01 to P.R.).

Publisher Copyright:
© 2016 Nature America, Inc. All rights reserved.

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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