Abstract
Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.
Original language | English |
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Pages (from-to) | 479-481 |
Number of pages | 3 |
Journal | Nature Chemical Biology |
Volume | 12 |
Issue number | 7 |
DOIs | |
Publication status | Published - 2016 Jul 1 |
Bibliographical note
Funding Information:This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (NRF-2013R1A1A2060447 to K.W.P.), and by the KRIBB Research Initiative Program (J.-S.L.). This study was also supported by the US National Institutes of Health (HL090553 to K.R. and F32 DK104484-01 to P.R.).
Publisher Copyright:
© 2016 Nature America, Inc. All rights reserved.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology