Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.
Bibliographical noteFunding Information:
This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (NRF-2013R1A1A2060447 to K.W.P.), and by the KRIBB Research Initiative Program (J.-S.L.). This study was also supported by the US National Institutes of Health (HL090553 to K.R. and F32 DK104484-01 to P.R.).
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ASJC Scopus subject areas
- Molecular Biology
- Cell Biology