TY - JOUR
T1 - Predicting hypertension among Korean cancer survivors
T2 - A nationwide population-based study
AU - Kim, Y. H.
AU - Cho, K. H.
AU - Kim, K. H.
AU - Ryu, E. J.
AU - Han, K. D.
AU - Kim, J. S.
N1 - Funding Information:
This study was funded by the National Research Foundation of Korea (NRF- 2015R1C1A1A02036408).
Publisher Copyright:
© 2018 John Wiley & Sons Ltd
PY - 2018/3
Y1 - 2018/3
N2 - Hypertension is the most common comorbidity among cancer survivors, although there is no model for predicting hypertension in this population. Therefore, we developed a model for predicting hypertension using data from 6,480 Korean cancer survivors who were ≥20 years old. The odds ratios (ORs) for hypertension were calculated using stepwise logistic regression analyses, and a nomogram was generated to predict hypertension. Hypertension was independently associated with an age of ≥65 years (OR: 3.058), male gender (OR: 1.195), obesity (OR: 1.998), prehypertension (OR: 2.06), dyslipidaemia (OR: 2.011) and diabetes mellitus (OR: 2.297). Each variable in the nomogram was assigned a specific number of points, and the total score (range: 0–400) was used to obtain a value for predicting hypertension. The estimated prevalence of hypertension increased when the total nomogram score exceeded the sixth decile (total points: 128; p for trend <.001). Therefore, among Korean cancer survivors, hypertension was significantly associated with an age of >65 years, male gender, obesity, and having various comorbidities (e.g., prehypertension, dyslipidaemia and diabetes mellitus). Furthermore, our nomogram could predict the incidence of hypertension, and the sixth decile of the total nomogram score predicted an increased risk of hypertension.
AB - Hypertension is the most common comorbidity among cancer survivors, although there is no model for predicting hypertension in this population. Therefore, we developed a model for predicting hypertension using data from 6,480 Korean cancer survivors who were ≥20 years old. The odds ratios (ORs) for hypertension were calculated using stepwise logistic regression analyses, and a nomogram was generated to predict hypertension. Hypertension was independently associated with an age of ≥65 years (OR: 3.058), male gender (OR: 1.195), obesity (OR: 1.998), prehypertension (OR: 2.06), dyslipidaemia (OR: 2.011) and diabetes mellitus (OR: 2.297). Each variable in the nomogram was assigned a specific number of points, and the total score (range: 0–400) was used to obtain a value for predicting hypertension. The estimated prevalence of hypertension increased when the total nomogram score exceeded the sixth decile (total points: 128; p for trend <.001). Therefore, among Korean cancer survivors, hypertension was significantly associated with an age of >65 years, male gender, obesity, and having various comorbidities (e.g., prehypertension, dyslipidaemia and diabetes mellitus). Furthermore, our nomogram could predict the incidence of hypertension, and the sixth decile of the total nomogram score predicted an increased risk of hypertension.
KW - Korean National Health Insurance Corporation
KW - cancer survivors
KW - hypertension
KW - nomogram
KW - prediction model
UR - http://www.scopus.com/inward/record.url?scp=85044356467&partnerID=8YFLogxK
U2 - 10.1111/ecc.12803
DO - 10.1111/ecc.12803
M3 - Article
C2 - 29333686
AN - SCOPUS:85044356467
SN - 0961-5423
VL - 27
JO - European Journal of Cancer Care
JF - European Journal of Cancer Care
IS - 2
M1 - e12803
ER -