Prediction of memory impairment with MRI data: A longitudinal study of Alzheimer’s disease

Xiaoqian Wang, Dinggang Shen, Heng Huang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Citations (Scopus)

Abstract

Alzheimer’s Disease (AD),a severe type of neurodegenerative disorder with progressive impairment of learning and memory,has threatened the health of millions of people. How to recognize AD at early stage is crucial. Multiple models have been presented to predict cognitive impairments by means of neuroimaging data. However,traditional models did not employ the valuable longitudinal information along the progression of the disease. In this paper,we proposed a novel longitudinal feature learning model to simultaneously uncover the interrelations among different cognitive measures at different time points and utilize such interrelated structures to enhance the learning of associations between imaging features and prediction tasks. Moreover,we adopted Schatten p-norm to identify the interrelation structures existing in the low-rank subspace. Empirical results on the ADNI cohort demonstrated promising performance of our model.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2016 - 19th International Conference, Proceedings
EditorsSebastian Ourselin, Leo Joskowicz, Mert R. Sabuncu, William Wells, Gozde Unal
PublisherSpringer Verlag
Pages273-281
Number of pages9
ISBN (Print)9783319467191
DOIs
Publication statusPublished - 2016
Event1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece
Duration: 2016 Oct 212016 Oct 21

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9900 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other1st International Workshop on Simulation and Synthesis in Medical Imaging, SASHIMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016
Country/TerritoryGreece
CityAthens
Period16/10/2116/10/21

Bibliographical note

Funding Information:
X. Wang and H. Huang were supported in part by NSF IIS-1117965, IIS-1302675, IIS-1344152, DBI-1356628, and NIH AG049371. D. Shen was supported in part by NIH AG041721.

Publisher Copyright:
© Springer International Publishing AG 2016.

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science

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