Predictive factors and survival rate for brain metastasis from breast cancer

Ah Lee Jung, Won Bae Jeoung, Uk Woo Sang, Bok Lee Jae, Whan Koo Byum

    Research output: Contribution to journalArticlepeer-review


    Purpose: The incidence of symptomatic brain metastases from breast cancerhas ranged from 10% to 16%. Brain metastases are traditionally viewed as a late complication of systemic disease, for which few effective treatment options exist. The aim of this study was to evaluate the factors that can predict brain metastases and to analyze the survival rate as compared with other systemic metastases. Methods: Between February 1983 and October 2005, 119 patient who developed systemic metastasis during the follow up period after optimal surgical treatment at Korea University Hospital were included in this study. Twenty-nine of these 119 patients had complaints of symptoms and they were consequently diagnosed as having brain metastases. Results: Estrogen receptor (-), progesterone receptor (-) and Her2 (-), and Triple negative were a significantly higher in the patients with brain metastases (p=0.04). The other clinicopathologic factors showed no difference between the patients with brain metastases and the patients without brain metastases. Lung metastases existed previously more often than the other systemic metastases (p=0.04). The overall survival of the patients with brain metastases was not significantly different from the patients with other systemic metastases. However, the disease specific survival of patients with brain metastases, as compared with other systemic metastases was poorer than that for patients with bone and lung metastases, respectively (p=0.01 and 0.03). A poor prognosis was shown for the cases with brain metastases within 1 yr after operation. Conclusion: Clinician should give attention to the possibility of brain metastases for the breast cancer patients with triple negative findings or the patients who have developed lung metastases as this represents a symptom of central nervous system.

    Original languageEnglish
    Pages (from-to)71-76
    Number of pages6
    JournalJournal of Breast Cancer
    Issue number2
    Publication statusPublished - 2008 Jun


    • Brain metastases
    • Breast cancer
    • Predictive factor
    • Survival

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research


    Dive into the research topics of 'Predictive factors and survival rate for brain metastasis from breast cancer'. Together they form a unique fingerprint.

    Cite this