Predictive Value of Radiologic Central Compartment Atopic Disease for Identifying Allergy and Asthma in Pediatric Patients

Kijeong Lee, Tae Hoon Kim, Sang Hag Lee, Chang Ho Kang, Bo-Kyung Je, Saelin Oh

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Introduction: Central compartment atopic disease (CCAD) has recently been suggested as a phenotype of chronic rhinosinusitis (CRS). This study aims to investigate the prevalence of the radiologic CCAD phenotype in CRS within a pediatric population and identify its ability to predict comorbid allergy and asthma. Methods: Computed tomography and endoscopic examination were conducted on pediatric patients with CRS either with or without nasal polyps. Allergen sensitization was determined with the multiple-allergen simultaneous test and skin prick test. Serum total immunoglobulin E (IgE), peripheral blood eosinophil percentage, and presence of asthma were also evaluated. Results: A total of 82 pediatric patients were enrolled. Overall, 55 (67.1%) of the participants demonstrated aeroallergen sensitization, and 31 (18.9%) of the 164 sides of sinuses were radiologically defined to fit the CCAD phenotype. Patients having CRS with the CCAD phenotype had a higher prevalence of aeroallergen sensitization (87.1% vs 62.4%, P =.008), particularly house dust mite (74.2% vs 53.4%, P =.035), and a higher incidence of asthma (16.1% vs 3.8%, P =.010). Additionally, patients having CRS with the CCAD phenotype demonstrated a high serum total IgE levels (51.6% vs 30.1%, P =.023) in comparison to patients having CRS without CCAD. Conclusion: In pediatric CRS, the radiological CCAD phenotype was associated with allergen sensitization and asthma. Furthermore, the CCAD phenotype was associated with high serum total IgE levels, suggesting allergy etiology should be considered with this type of pediatric patients with CRS.

Original languageEnglish
Pages (from-to)593-599
Number of pages7
JournalEar, Nose and Throat Journal
Issue number9
Publication statusPublished - 2022 Nov

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O2000711, O2000721).

Publisher Copyright:
© The Author(s) 2021.


  • allergy
  • central compartment atopic disease
  • chronic rhinosinusitis
  • computed tomography
  • pediatrics

ASJC Scopus subject areas

  • Otorhinolaryngology


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