Predictive value of urinary and serum biomarkers in young children with febrile urinary tract infections

Hyung Eun Yim, Hyungshin Yim, Eun Soo Bae, Sang Uk Woo, Kee Hwan Yoo

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Background: Early predictive biomarkers for the diagnosis and management of febrile urinary tract infections (UTIs) can be valuable diagnostic tools in children.

Methods: The study cohort comprised 73 pediatric patients with febrile UTIs [46 with acute pyelonephritis (APN) and 27 with lower UTIs] and 56 healthy children. Urine neutrophil gelatinase-associated lipocalin (uNGAL) and kidney injury molecule-1 (uKIM-1) levels and serum cystatin C (sCysC) levels were measured.

Results: The uNGAL/creatinine (Cr) and uKIM-1/Cr levels were higher in the UTI group than in the controls (P < 0.05). uNGAL/Cr and sCysC levels were higher in patients with APN than in those with lower UTIs (P < 0.05). uNGAL/Cr levels in both the APN and UTI groups decreased following the administration of antibiotics compared to those before treatment (P < 0.05). The uNGAL/Cr level was correlated with serum levels of white blood cells, C-reactive protein, CysC and with uKIM-1/Cr (P < 0.05). uKIM-1/Cr was also correlated with sCysC (P < 0.05). Receiver operating curve analyses showed good diagnostic profiles of uNGAL/Cr and uKIM-1/Cr for identifying UTIs [area under the curve (AUC) 0.9 and 0.66, respectively) and of uNGAL/Cr and sCysC for predicting APN (AUC 0.78 and 0.72, respectively).

Conclusions: Our results suggest that uNGAL, uKIM-1 and sCysC levels may be useful for predicting and managing febrile UTIs in children.

Original languageEnglish
Pages (from-to)2181-2189
Number of pages9
JournalPediatric Nephrology
Issue number11
Publication statusPublished - 2014 Nov
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by a Korea University Grant (K1131761).

Publisher Copyright:
© 2014, IPNA.


  • Acute kidney injury
  • Bacterial infections
  • Biomarkers
  • Child
  • Pyelonephritis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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