Preparation and antibacterial activity of chitosan microshperes in a solid dispersing system

Ming Kong, Xi Guang Chen, Yu Ping Xue, Cheng Sheng Liu, Le Jun Yu, Qiu Xia Ji, Dong Su Cha, Hyun Jin Park

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61 Citations (Scopus)


In this study, we investigated the interface contacting inhibition behaviors of chitosan against bacterial in the dispersing state. For that purpose, chitosan microspheres (CMs) in the dispersing state was prepared by the emulsification cross-linking method. The CMs had smooth surface and spherical shape with the diameter of about 124 μm. They were stable after sterilization at 121°C and 150 kPa for 20 min. The CMs had similar antibacterial activity to that of chitosan in the solution form. Their antibacterial activities increased with the increase of the CM concentration, while decreased with the increase of pH of the system. It was found that the CMs with the degree of deacetylation (DD) of 63.6% exhibited the highest antibacterial activity, while the CMs with the DD of 83.7% exerted the lowest antibacterial activity among the three tested samples.

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalFrontiers of Materials Science in China
Issue number2
Publication statusPublished - 2008 Jun

Bibliographical note

Funding Information:
Acknowledgements The authors are indebted to the financial support from the National Natural Science Foundation of China (Grant No. 30770582) and the International S&T Cooperation Program of China (NSFC No.2006DFA33150).


  • Antibacterial activity
  • Chitosan
  • Dispersing system
  • Microsphere

ASJC Scopus subject areas

  • General Materials Science


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