Preparation and characterization of chitosan microparticles intended for controlled drug delivery

J. A. Ko, H. J. Park, S. J. Hwang, J. B. Park, J. S. Lee

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    427 Citations (Scopus)

    Abstract

    Chitosan microparticles were prepared with tripolyphosphate (TPP) by ionic crosslinking. The particle sizes of TPP-chitosan microparticles were in range from 500 to 710 μm and encapsulation efficiencies of drug were more than 90%. The morphologies of TPP-chitosan microparticles were examined with scanning electron microscopy. As pH of TPP solution decreased and molecular weight (MW) of chitosan increased, microparticles had more spherical shape and smooth surface. Release behaviors of felodipine as a model drug were affected by various preparation processes. Chitosan microparticles prepared with lower pH or higher concentration of TPP solution resulted in slower felodipine release from microparticles. With decreasing MW and concentration of chitosan solution, release behavior was increased. The release of drug from TPP-chitosan microparticles decreased when cross-linking time increased. These results indicate that TPP-chitosan microparticles may become a potential delivery system to control the release of drug.

    Original languageEnglish
    Pages (from-to)165-174
    Number of pages10
    JournalInternational Journal of Pharmaceutics
    Volume249
    Issue number1-2
    DOIs
    Publication statusPublished - 2002 Dec 5

    Bibliographical note

    Funding Information:
    This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-00-PT-21700-0017).

    Keywords

    • Chitosan
    • Drug delivery system
    • Microparticle
    • Tripolyphosphate

    ASJC Scopus subject areas

    • Pharmaceutical Science

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