Preparation and properties of PHEA/chitosan composite hydrogel

Jeong Hoon Kim; Sang Jun Sim; Dong Hyun Lee; Dukjoon Kim; Young Kwan Lee; Dong June Chung; Ji Heung Kim

doi:10.1295/polymj.36.943

Preparation and properties of PHEA/chitosan composite hydrogel

Jeong Hoon Kim, Sang Jun Sim, Dong Hyun Lee, Dukjoon Kim, Young Kwan Lee, Dong June Chung, Ji Heung Kim

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Biodegradable hydrogels based on synthetic PHEA and IPN type composite hydrogel with chitosan, a natural carbohydrate polymer, were prepared by crosslinking using glutaraldehyde in aqueous mixture. Relatively strong hydrogels were formed in a shaped mold. Preparation of crosslinked gels and their swelling behavior depending on the composition, medium, and pH of solution are investigated. The porous morphology of scaffolds, obtained by freeze-drying method, was observed by scanning electron microscopy. Also preliminary results/on hydrolytic degradation and cytotoxicity test of the hydrogel are included.

Original language	English
Pages (from-to)	943-948
Number of pages	6
Journal	Polymer Journal
Volume	36
Issue number	12
DOIs	https://doi.org/10.1295/polymj.36.943
Publication status	Published - 2004
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgment. This work was supported by the Korea Research Foundation Grant (KRF-2004-005-D00070).

Keywords

Biodegradation
Chitosan
Hydrogel
Polyhydroxyethyl aspartamide
Scaffold
Swelling Behavior
pH-Sensitive

ASJC Scopus subject areas

Polymers and Plastics
Materials Chemistry

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10.1295/polymj.36.943

Cite this

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abstract = "Biodegradable hydrogels based on synthetic PHEA and IPN type composite hydrogel with chitosan, a natural carbohydrate polymer, were prepared by crosslinking using glutaraldehyde in aqueous mixture. Relatively strong hydrogels were formed in a shaped mold. Preparation of crosslinked gels and their swelling behavior depending on the composition, medium, and pH of solution are investigated. The porous morphology of scaffolds, obtained by freeze-drying method, was observed by scanning electron microscopy. Also preliminary results/on hydrolytic degradation and cytotoxicity test of the hydrogel are included.",

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doi = "10.1295/polymj.36.943",

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T1 - Preparation and properties of PHEA/chitosan composite hydrogel

AU - Kim, Jeong Hoon

AU - Sim, Sang Jun

AU - Lee, Dong Hyun

AU - Kim, Dukjoon

AU - Lee, Young Kwan

AU - Chung, Dong June

AU - Kim, Ji Heung

N1 - Funding Information: Acknowledgment. This work was supported by the Korea Research Foundation Grant (KRF-2004-005-D00070).

PY - 2004

Y1 - 2004

N2 - Biodegradable hydrogels based on synthetic PHEA and IPN type composite hydrogel with chitosan, a natural carbohydrate polymer, were prepared by crosslinking using glutaraldehyde in aqueous mixture. Relatively strong hydrogels were formed in a shaped mold. Preparation of crosslinked gels and their swelling behavior depending on the composition, medium, and pH of solution are investigated. The porous morphology of scaffolds, obtained by freeze-drying method, was observed by scanning electron microscopy. Also preliminary results/on hydrolytic degradation and cytotoxicity test of the hydrogel are included.

AB - Biodegradable hydrogels based on synthetic PHEA and IPN type composite hydrogel with chitosan, a natural carbohydrate polymer, were prepared by crosslinking using glutaraldehyde in aqueous mixture. Relatively strong hydrogels were formed in a shaped mold. Preparation of crosslinked gels and their swelling behavior depending on the composition, medium, and pH of solution are investigated. The porous morphology of scaffolds, obtained by freeze-drying method, was observed by scanning electron microscopy. Also preliminary results/on hydrolytic degradation and cytotoxicity test of the hydrogel are included.

KW - Biodegradation

KW - Chitosan

KW - Hydrogel

KW - Polyhydroxyethyl aspartamide

KW - Scaffold

KW - Swelling Behavior

KW - pH-Sensitive

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Preparation and properties of PHEA/chitosan composite hydrogel

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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