Preparation and properties of PHEA/chitosan composite hydrogel

Jeong Hoon Kim, Sang Jun Sim, Dong Hyun Lee, Dukjoon Kim, Young Kwan Lee, Dong June Chung, Ji Heung Kim

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Biodegradable hydrogels based on synthetic PHEA and IPN type composite hydrogel with chitosan, a natural carbohydrate polymer, were prepared by crosslinking using glutaraldehyde in aqueous mixture. Relatively strong hydrogels were formed in a shaped mold. Preparation of crosslinked gels and their swelling behavior depending on the composition, medium, and pH of solution are investigated. The porous morphology of scaffolds, obtained by freeze-drying method, was observed by scanning electron microscopy. Also preliminary results/on hydrolytic degradation and cytotoxicity test of the hydrogel are included.

Original languageEnglish
Pages (from-to)943-948
Number of pages6
JournalPolymer Journal
Issue number12
Publication statusPublished - 2004
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgment. This work was supported by the Korea Research Foundation Grant (KRF-2004-005-D00070).


  • Biodegradation
  • Chitosan
  • Hydrogel
  • Polyhydroxyethyl aspartamide
  • Scaffold
  • Swelling Behavior
  • pH-Sensitive

ASJC Scopus subject areas

  • Polymers and Plastics
  • Materials Chemistry


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