Preparation and release characteristics of polymer-coated and blended alginate microspheres

D. W. Lee, S. J. Hwang, J. B. Park, H. J. Park

Research output: Contribution to journalReview articlepeer-review

109 Citations (Scopus)


To prevent a rapid drug release from alginate microspheres in simulated intestinal media, alginate microspheres were coated or blended with polymers. Three polymers were selected and evaluated such as HPMC, Eudragit RS 30D and chitosan, as both coating materials and additive polymers for controlling the drug release. This study focused on the release characteristics of polymer-coated and blended alginate microspheres, varying the type of polymer and its concentration. The alginate microspheres were prepared by dropping the mixture of drug and sodium alginate into CaCl2 solution using a spray-gun. Polymer-coated microspheres were prepared by adding alginate microspheres into polymer solution with mild stirring. Polymer-blended microspheres were prepared by dropping the mixture of drug, sodium alginate and additive polymer with plasticizer into CaCl2 solution. In vitro release test was carried out to investigate the release profiles in 500ml of phosphate buffered saline (PBS, pH 7.4). As the amount of polymer in sodium alginate or coating solution increase, the drug release generally decreased. HPMC-blended microspheres swelled but withstood the disintegration, showing an ideal linear release profiles. Chitosan-coated microspheres showed smooth and round surface and extended the release of drug. In comparison with chitosan-coated microspheres, HPMC-blended alginate microspheres can be easily made and used for controlled drug delivery systems due to convenient process and controlled drug release.

Original languageEnglish
Pages (from-to)179-192
Number of pages14
JournalJournal of Microencapsulation
Issue number2
Publication statusPublished - 2003 Mar
Externally publishedYes

Bibliographical note

Funding Information:
rI lhis study \\tiis supported by a grant of the Korea I-Iealth 21 R&D Project, Nlinistry of Health k \Velfare, Republic of Korea (Hh4P-OO-P'r-21 700-001 7).


  • Alginate
  • Chitosan
  • HPMC
  • Microspheres
  • Polymer-blending
  • Polymer-coating

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry


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