Preparation and rheological properties of deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems

Hong Tao Pang, Xi Guang Chen, Hyun Jin Park, Dong Su Cha, John F. Kennedy

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Self-aggregation and micelles of amphiphatic polymers are important functions in application, and their properties are influenced by the parent hydrophilic polymer and the hydrophobic groups. In this paper, deoxycholate-chitosan (DE-chitosan) and carboxymethyl-chitosan (CM-chitosan) were prepared from chitosan (MW, 28 kDa; DD, 90%). The effects of acid, pH and ionic concentrations on aggregation behaviors of the polymers in aqueous systems were measured, respectively. The ionic strength was found to enhance the aggregation of DE-chitosan, but had no influence to CM-chitosan and chitosan itself. The modification of hydrophobic groups and hydrophilic groups influenced the rheology properties of both parent chitosan and the derivatives. The assemblage of DE-chitosan in solution can be controlled by an oil/water (methylene chloride/DE-chitosan solution) emulsification process using methylene chloride. The micelles of DE-chitosan formed nano-micelles particles of 200-600 nm in diameter which can be used to encapsulate lipid-soluble compounds for drug dispersing and delivery releasing.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalCarbohydrate Polymers
Issue number3
Publication statusPublished - 2007 Jun 25

Bibliographical note

Funding Information:
We acknowledge the ISTCP(2006DFA33150), NSFC (30670566) and KOSEF (1999-2-220-009-4) for the financial support in this study.


  • Chitosan
  • Micelle
  • Modification
  • Nanoparticle
  • Rheology

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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