Abstract
Hexanoyl chitosan was synthesized through a coupling reaction between chitosan and hexanoic anhydride. Proton nuclear magnetic resonance ( 1 HNMR) and fourier-transform infrared (FTIR) spectroscopy studies showed the formation of hexanoyl chitosan. The nanoparticles of hexanoyl chitosan were prepared through ionotropic gelation with tripolyphosphate (TPP) followed by sonication. The hexanoyl chitosan-TPP nanoparticles exhibited uniform spherical shape with smooth surface as observed by atomic force microscopy and transmission electron microscopy. The particle size of nanoparticles was between 54.1 to 724 nm with a mean diameter of 324 nm. At 0.2, 0.4, and 0.6 mg/mL bovine serum albumin initial concentration, the encapsulation efficiency and loading capacity of hexanoyl-chitosan-TPP nanoparticles were 58.2, 44.5, and 28.1%, and 14.1, 23.4, and 30.3%, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 375-381 |
| Number of pages | 7 |
| Journal | Drug Delivery |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2006 Oct 1 |
Bibliographical note
Funding Information:Received 4 July 2005; accepted 22 August 2005. This study was supported by the grants of the Korea Health 21 R&D project, Ministry of Health & Welfare, Republic of Korea (A050376) and Korea University. ∗Current address: Dept. of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA. Address correspondence to Prof. Hyun Jin Park, School of Life Sciences and Biotechnology, Korea University, 1, 5-Ka, Anam-Dong, Sungbuk-ku, Seoul-136-701, South Korea. E-mail: [email protected]
Keywords
- Chitosan
- Hexanoyl Chitosan
- Nanoparticles
- Protein Delivery
ASJC Scopus subject areas
- Pharmaceutical Science