Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration

Jee Hye Kim, Jung A. Ko, Jun Tae Kim, Dong Su Cha, Jin Hun Cho, Hyun Jin Park, Gye Hwa Shin

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)


Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.

Original languageEnglish
Pages (from-to)725-732
Number of pages8
JournalJournal of agricultural and food chemistry
Issue number3
Publication statusPublished - 2014 Jan 22


  • HLB value
  • capsaicin
  • confocal microscopy
  • nanoemulsion
  • skin penetration

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences


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