Abstract
Acetylated chitosan sponges (chitin sponges) were prepared according to acetylation time (25, 50, 75, and 100 h). As the acetylation time increased, the degree of acetylation increased, and a 75-h acetylation time produced the highest degree of acetylation (DA). The surface morphologies of samples were examined by scanning electron microscopy. Sponge samples were shown by a water uptake ability test to have higher water absorption abilities. An in vitro biodegradation test showed that sponges with a higher DA were more susceptible to lysozyme hydrolysis. Acetylated chitosan sponges were further shown by an in vitro fibroblast proliferation test to have a higher degree of cell viability on increasing the DA, with 75 h exhibiting the maximum effect. The results showed that the wound healing effect of chitosan sponges can be controlled by the DA.
Original language | English |
---|---|
Pages (from-to) | 1618-1623 |
Number of pages | 6 |
Journal | Journal of Applied Polymer Science |
Volume | 117 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 Aug 1 |
Externally published | Yes |
Keywords
- Chitin
- Chitosan
- Degree of acetylation
- Ound healing
- Sponge
ASJC Scopus subject areas
- Chemistry(all)
- Surfaces, Coatings and Films
- Polymers and Plastics
- Materials Chemistry