Preparation of acetylated chitosan sponges (Chitin Sponges)

Jung A. Ko, Bum Keun Kim, Hyun Jin Park

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Acetylated chitosan sponges (chitin sponges) were prepared according to acetylation time (25, 50, 75, and 100 h). As the acetylation time increased, the degree of acetylation increased, and a 75-h acetylation time produced the highest degree of acetylation (DA). The surface morphologies of samples were examined by scanning electron microscopy. Sponge samples were shown by a water uptake ability test to have higher water absorption abilities. An in vitro biodegradation test showed that sponges with a higher DA were more susceptible to lysozyme hydrolysis. Acetylated chitosan sponges were further shown by an in vitro fibroblast proliferation test to have a higher degree of cell viability on increasing the DA, with 75 h exhibiting the maximum effect. The results showed that the wound healing effect of chitosan sponges can be controlled by the DA.

Original languageEnglish
Pages (from-to)1618-1623
Number of pages6
JournalJournal of Applied Polymer Science
Issue number3
Publication statusPublished - 2010 Aug 1
Externally publishedYes


  • Chitin
  • Chitosan
  • Degree of acetylation
  • Ound healing
  • Sponge

ASJC Scopus subject areas

  • General Chemistry
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry


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