Preparation of aqueous alpha-lipoic acid dispersions with octenylsuccinylated high amylose starch

Yi Xuan Li; Seung Taik Lim

doi:10.1016/j.carbpol.2015.12.023

Preparation of aqueous alpha-lipoic acid dispersions with octenylsuccinylated high amylose starch

Yi Xuan Li, Seung Taik Lim

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Aqueous dispersions prepared with OSA-modified high amylose starch were investigated in comparison with native high amylose starch and beta-cyclodextrin using alpha-lipoic acid as a model substance. Alpha-lipoic acid (ALA), a lipophilic antioxidant essential for energy metabolism in human, was dispersed in gelatinized starch solutions (1.0% w/v) at different temperatures (50-90 °C) and times (3-12 h). High amylose starch modified with 3% OSA (dry starch base) was most favored in maximizing the dispersibility of ALA (84% recovery) under mild heating (70 °C for 3 h). The optimally prepared dispersion was milky white and contained particles with a narrow size distribution (200-300 nm). The precipitate isolated from the dispersion contained crystalline V-complexes of ALA and amylose while the supernatant contained free ALA accounting for 1/3 of total ALA, indicating OSA-modified high amylose starch stabilized ALA either by complexing with amylose or by retarding aggregation of ALA.

Original language	English
Pages (from-to)	253-259
Number of pages	7
Journal	Carbohydrate Polymers
Volume	140
DOIs	https://doi.org/10.1016/j.carbpol.2015.12.023
Publication status	Published - 2016 Apr 20

Bibliographical note

Funding Information:
This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2014R1A2A2A01007996).

Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.

Keywords

Alpha-lipoic acid
High amylose starch
Nano-dispersion
Octenylsuccinylated starch
V-complex

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2015.12.023

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title = "Preparation of aqueous alpha-lipoic acid dispersions with octenylsuccinylated high amylose starch",

abstract = "Aqueous dispersions prepared with OSA-modified high amylose starch were investigated in comparison with native high amylose starch and beta-cyclodextrin using alpha-lipoic acid as a model substance. Alpha-lipoic acid (ALA), a lipophilic antioxidant essential for energy metabolism in human, was dispersed in gelatinized starch solutions (1.0% w/v) at different temperatures (50-90 °C) and times (3-12 h). High amylose starch modified with 3% OSA (dry starch base) was most favored in maximizing the dispersibility of ALA (84% recovery) under mild heating (70 °C for 3 h). The optimally prepared dispersion was milky white and contained particles with a narrow size distribution (200-300 nm). The precipitate isolated from the dispersion contained crystalline V-complexes of ALA and amylose while the supernatant contained free ALA accounting for 1/3 of total ALA, indicating OSA-modified high amylose starch stabilized ALA either by complexing with amylose or by retarding aggregation of ALA.",

keywords = "Alpha-lipoic acid, High amylose starch, Nano-dispersion, Octenylsuccinylated starch, V-complex",

author = "Li, {Yi Xuan} and Lim, {Seung Taik}",

note = "Funding Information: This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2014R1A2A2A01007996). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",

year = "2016",

month = apr,

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doi = "10.1016/j.carbpol.2015.12.023",

language = "English",

volume = "140",

pages = "253--259",

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AU - Li, Yi Xuan

AU - Lim, Seung Taik

N1 - Funding Information: This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2014R1A2A2A01007996). Publisher Copyright: © 2015 Elsevier Ltd. All rights reserved.

PY - 2016/4/20

Y1 - 2016/4/20

N2 - Aqueous dispersions prepared with OSA-modified high amylose starch were investigated in comparison with native high amylose starch and beta-cyclodextrin using alpha-lipoic acid as a model substance. Alpha-lipoic acid (ALA), a lipophilic antioxidant essential for energy metabolism in human, was dispersed in gelatinized starch solutions (1.0% w/v) at different temperatures (50-90 °C) and times (3-12 h). High amylose starch modified with 3% OSA (dry starch base) was most favored in maximizing the dispersibility of ALA (84% recovery) under mild heating (70 °C for 3 h). The optimally prepared dispersion was milky white and contained particles with a narrow size distribution (200-300 nm). The precipitate isolated from the dispersion contained crystalline V-complexes of ALA and amylose while the supernatant contained free ALA accounting for 1/3 of total ALA, indicating OSA-modified high amylose starch stabilized ALA either by complexing with amylose or by retarding aggregation of ALA.

AB - Aqueous dispersions prepared with OSA-modified high amylose starch were investigated in comparison with native high amylose starch and beta-cyclodextrin using alpha-lipoic acid as a model substance. Alpha-lipoic acid (ALA), a lipophilic antioxidant essential for energy metabolism in human, was dispersed in gelatinized starch solutions (1.0% w/v) at different temperatures (50-90 °C) and times (3-12 h). High amylose starch modified with 3% OSA (dry starch base) was most favored in maximizing the dispersibility of ALA (84% recovery) under mild heating (70 °C for 3 h). The optimally prepared dispersion was milky white and contained particles with a narrow size distribution (200-300 nm). The precipitate isolated from the dispersion contained crystalline V-complexes of ALA and amylose while the supernatant contained free ALA accounting for 1/3 of total ALA, indicating OSA-modified high amylose starch stabilized ALA either by complexing with amylose or by retarding aggregation of ALA.

KW - Alpha-lipoic acid

KW - High amylose starch

KW - Nano-dispersion

KW - Octenylsuccinylated starch

KW - V-complex

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SN - 0144-8617

VL - 140

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JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

ER -

Preparation of aqueous alpha-lipoic acid dispersions with octenylsuccinylated high amylose starch

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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