Preparation of Chitosan-Coated Nanostructured Lipid Carriers (CH-NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System

Sun Ah Lee; Hee Joung Joung; Hyun Jin Park; Gye Hwa Shin

doi:10.1111/1750-3841.13655

Preparation of Chitosan-Coated Nanostructured Lipid Carriers (CH-NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System

Sun Ah Lee, Hee Joung Joung, Hyun Jin Park, Gye Hwa Shin

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Nanostructured lipid carriers (NLCs) and chitosan-coated NLCs (CH-NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 ± 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH-NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH-NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH-NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH-NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk-fortified NLC and CH-NLCs was lower than that of original milk. Based on these results, CH-NLCs showed great potential for iron fortification in milk.

Original language	English
Pages (from-to)	904-912
Number of pages	9
Journal	Journal of Food Science
Volume	82
Issue number	4
DOIs	https://doi.org/10.1111/1750-3841.13655
Publication status	Published - 2017 Apr 1

Bibliographical note

Funding Information:
This research was supported by Korea university grant, School of Life Sciences and Biotechnology for BK21PLUS, Korea University, Institute of Biomedical Science & Food Safety, Korea University, by grant 20130290 to the Solar Salt Research Center of Mokpo National University from the Ministry of Oceans and Fisheries of Korea, and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant number: NRF-2015R1D1A4A01019211).

Publisher Copyright:
© 2017 Institute of Food Technologists®

Keywords

chitosan
ferric pyrophosphate (FePP)
iron fortification
nanostructured lipid carriers (NLCs)
palm oil

ASJC Scopus subject areas

Food Science

Access to Document

10.1111/1750-3841.13655

Cite this

@article{1ea4f8463b394d93b7215657cd16e89f,

title = "Preparation of Chitosan-Coated Nanostructured Lipid Carriers (CH-NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System",

abstract = "Nanostructured lipid carriers (NLCs) and chitosan-coated NLCs (CH-NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 ± 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH-NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH-NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH-NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH-NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk-fortified NLC and CH-NLCs was lower than that of original milk. Based on these results, CH-NLCs showed great potential for iron fortification in milk.",

keywords = "chitosan, ferric pyrophosphate (FePP), iron fortification, nanostructured lipid carriers (NLCs), palm oil",

author = "Lee, {Sun Ah} and Joung, {Hee Joung} and Park, {Hyun Jin} and Shin, {Gye Hwa}",

note = "Funding Information: This research was supported by Korea university grant, School of Life Sciences and Biotechnology for BK21PLUS, Korea University, Institute of Biomedical Science & Food Safety, Korea University, by grant 20130290 to the Solar Salt Research Center of Mokpo National University from the Ministry of Oceans and Fisheries of Korea, and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant number: NRF-2015R1D1A4A01019211). Publisher Copyright: {\textcopyright} 2017 Institute of Food Technologists{\textregistered}",

year = "2017",

month = apr,

day = "1",

doi = "10.1111/1750-3841.13655",

language = "English",

volume = "82",

pages = "904--912",

journal = "Journal of Food Science",

issn = "0022-1147",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Preparation of Chitosan-Coated Nanostructured Lipid Carriers (CH-NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System

AU - Lee, Sun Ah

AU - Joung, Hee Joung

AU - Park, Hyun Jin

AU - Shin, Gye Hwa

N1 - Funding Information: This research was supported by Korea university grant, School of Life Sciences and Biotechnology for BK21PLUS, Korea University, Institute of Biomedical Science & Food Safety, Korea University, by grant 20130290 to the Solar Salt Research Center of Mokpo National University from the Ministry of Oceans and Fisheries of Korea, and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant number: NRF-2015R1D1A4A01019211). Publisher Copyright: © 2017 Institute of Food Technologists®

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Nanostructured lipid carriers (NLCs) and chitosan-coated NLCs (CH-NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 ± 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH-NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH-NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH-NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH-NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk-fortified NLC and CH-NLCs was lower than that of original milk. Based on these results, CH-NLCs showed great potential for iron fortification in milk.

AB - Nanostructured lipid carriers (NLCs) and chitosan-coated NLCs (CH-NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 ± 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH-NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH-NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH-NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH-NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk-fortified NLC and CH-NLCs was lower than that of original milk. Based on these results, CH-NLCs showed great potential for iron fortification in milk.

KW - chitosan

KW - ferric pyrophosphate (FePP)

KW - iron fortification

KW - nanostructured lipid carriers (NLCs)

KW - palm oil

UR - http://www.scopus.com/inward/record.url?scp=85013910805&partnerID=8YFLogxK

U2 - 10.1111/1750-3841.13655

DO - 10.1111/1750-3841.13655

M3 - Article

C2 - 28241098

AN - SCOPUS:85013910805

SN - 0022-1147

VL - 82

SP - 904

EP - 912

JO - Journal of Food Science

JF - Journal of Food Science

IS - 4

ER -

Preparation of Chitosan-Coated Nanostructured Lipid Carriers (CH-NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this