Preparation of Chitosan-Coated Nanostructured Lipid Carriers (CH-NLCs) to Control Iron Delivery and Their Potential Application to Food Beverage System

Sun Ah Lee, Hee Joung Joung, Hyun Jin Park, Gye Hwa Shin

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Nanostructured lipid carriers (NLCs) and chitosan-coated NLCs (CH-NLCs) were prepared by a combined double emulsion and melt dispersion method. The physicochemical properties of them were investigated to determine the optimum conditions. At 3% emulsifier concentration, the NLCs showed about 191.0 ± 4.1 nm mean particle size and low polydispersity index value compared to those observed under other conditions. The encapsulation efficiency of CH-NLCs was 83.9% which was about 10% higher than that of NLCs. In vitro release test showed that low release amount of iron from the NLCs (11%) and CH-NLCs (5%) in simulated gastric condition within 3 h, whereas the iron release amounts of the NLCs and CH-NLCs were high (over 77%) in simulated intestinal condition because both NLCs and CH-NLCs were totally destructed in the intestinal condition after 3 h. In the thiobarbituric acid test, the absorbance of milk-fortified NLC and CH-NLCs was lower than that of original milk. Based on these results, CH-NLCs showed great potential for iron fortification in milk.

Original languageEnglish
Pages (from-to)904-912
Number of pages9
JournalJournal of Food Science
Volume82
Issue number4
DOIs
Publication statusPublished - 2017 Apr 1

Bibliographical note

Funding Information:
This research was supported by Korea university grant, School of Life Sciences and Biotechnology for BK21PLUS, Korea University, Institute of Biomedical Science & Food Safety, Korea University, by grant 20130290 to the Solar Salt Research Center of Mokpo National University from the Ministry of Oceans and Fisheries of Korea, and by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (Grant number: NRF-2015R1D1A4A01019211).

Publisher Copyright:
© 2017 Institute of Food Technologists®

Keywords

  • chitosan
  • ferric pyrophosphate (FePP)
  • iron fortification
  • nanostructured lipid carriers (NLCs)
  • palm oil

ASJC Scopus subject areas

  • Food Science

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