Preparation of electrospun poly(l-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application

Hyung Il Kim; Ryosuke Matsuno; Ji Hun Seo; Tomohiro Konno; Madoka Takai; Kazuhiko Ishihara

doi:10.1016/j.cap.2009.06.001

Preparation of electrospun poly(l-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application

Hyung Il Kim, Ryosuke Matsuno, Ji Hun Seo, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Nanopores generated from the gap among electrospun nanofibers can provide vascular tissues with oxygen, nutrients, and growth factors. Here, we report the first fabrication of poly(l-lactide-co-caprolactone-co-glycolide) (PLCG) electrospun nanofibers. A water-soluble amphiphilic copolymer bearing phosphorylcholine groups (PMB30W) and an antiproliferative (rapamycin) were incorporated into PLCG by solvent blending and subsequent electrospinning. The nanostructure of the electrospun PLCG/PMB30W/rapamycin blended fibers was stable during incubation in phosphate-buffered saline without addition of chemical crosslinkers. Amphiphilic characteristics of PMB30W and hydrophobic nature of rapamycin could make the electrospun PLCG/PMB30W/rapamycin blended fibers stable under a physiologic condition. The electrospun PLCG/PMB30W/rapamycin blended fibers may be preferable for vascular prostheses and tissue-engineered vascular grafts.

Original language	English
Pages (from-to)	e249-e251
Journal	Current Applied Physics
Volume	9
Issue number	4 SUPPL.
DOIs	https://doi.org/10.1016/j.cap.2009.06.001
Publication status	Published - 2009 Jul
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported in part by Global-COE Program, Center for Medical System Innovation, MEXT, Japan.

Keywords

Artificial vessels
Electrospinning
Phospholipid polymer
Rapamycin
poly(l-lactide-co-caprolactone-co-glycolide)

ASJC Scopus subject areas

General Materials Science
General Physics and Astronomy

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10.1016/j.cap.2009.06.001

Cite this

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title = "Preparation of electrospun poly(l-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application",

abstract = "Nanopores generated from the gap among electrospun nanofibers can provide vascular tissues with oxygen, nutrients, and growth factors. Here, we report the first fabrication of poly(l-lactide-co-caprolactone-co-glycolide) (PLCG) electrospun nanofibers. A water-soluble amphiphilic copolymer bearing phosphorylcholine groups (PMB30W) and an antiproliferative (rapamycin) were incorporated into PLCG by solvent blending and subsequent electrospinning. The nanostructure of the electrospun PLCG/PMB30W/rapamycin blended fibers was stable during incubation in phosphate-buffered saline without addition of chemical crosslinkers. Amphiphilic characteristics of PMB30W and hydrophobic nature of rapamycin could make the electrospun PLCG/PMB30W/rapamycin blended fibers stable under a physiologic condition. The electrospun PLCG/PMB30W/rapamycin blended fibers may be preferable for vascular prostheses and tissue-engineered vascular grafts.",

keywords = "Artificial vessels, Electrospinning, Phospholipid polymer, Rapamycin, poly(l-lactide-co-caprolactone-co-glycolide)",

author = "Kim, {Hyung Il} and Ryosuke Matsuno and Seo, {Ji Hun} and Tomohiro Konno and Madoka Takai and Kazuhiko Ishihara",

note = "Funding Information: This work was supported in part by Global-COE Program, Center for Medical System Innovation, MEXT, Japan.",

year = "2009",

month = jul,

doi = "10.1016/j.cap.2009.06.001",

language = "English",

volume = "9",

pages = "e249--e251",

journal = "Current Applied Physics",

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AU - Kim, Hyung Il

AU - Matsuno, Ryosuke

AU - Seo, Ji Hun

AU - Konno, Tomohiro

AU - Takai, Madoka

AU - Ishihara, Kazuhiko

N1 - Funding Information: This work was supported in part by Global-COE Program, Center for Medical System Innovation, MEXT, Japan.

PY - 2009/7

Y1 - 2009/7

N2 - Nanopores generated from the gap among electrospun nanofibers can provide vascular tissues with oxygen, nutrients, and growth factors. Here, we report the first fabrication of poly(l-lactide-co-caprolactone-co-glycolide) (PLCG) electrospun nanofibers. A water-soluble amphiphilic copolymer bearing phosphorylcholine groups (PMB30W) and an antiproliferative (rapamycin) were incorporated into PLCG by solvent blending and subsequent electrospinning. The nanostructure of the electrospun PLCG/PMB30W/rapamycin blended fibers was stable during incubation in phosphate-buffered saline without addition of chemical crosslinkers. Amphiphilic characteristics of PMB30W and hydrophobic nature of rapamycin could make the electrospun PLCG/PMB30W/rapamycin blended fibers stable under a physiologic condition. The electrospun PLCG/PMB30W/rapamycin blended fibers may be preferable for vascular prostheses and tissue-engineered vascular grafts.

AB - Nanopores generated from the gap among electrospun nanofibers can provide vascular tissues with oxygen, nutrients, and growth factors. Here, we report the first fabrication of poly(l-lactide-co-caprolactone-co-glycolide) (PLCG) electrospun nanofibers. A water-soluble amphiphilic copolymer bearing phosphorylcholine groups (PMB30W) and an antiproliferative (rapamycin) were incorporated into PLCG by solvent blending and subsequent electrospinning. The nanostructure of the electrospun PLCG/PMB30W/rapamycin blended fibers was stable during incubation in phosphate-buffered saline without addition of chemical crosslinkers. Amphiphilic characteristics of PMB30W and hydrophobic nature of rapamycin could make the electrospun PLCG/PMB30W/rapamycin blended fibers stable under a physiologic condition. The electrospun PLCG/PMB30W/rapamycin blended fibers may be preferable for vascular prostheses and tissue-engineered vascular grafts.

KW - Artificial vessels

KW - Electrospinning

KW - Phospholipid polymer

KW - Rapamycin

KW - poly(l-lactide-co-caprolactone-co-glycolide)

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DO - 10.1016/j.cap.2009.06.001

M3 - Article

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SN - 1567-1739

VL - 9

SP - e249-e251

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ER -

Preparation of electrospun poly(l-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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