Preparation of enhanced hydrophobic poly(l-lactide-co-ε-caprolactone) films surface and its blood compatibility

Seung Il Kim, Jin Ik Lim, Youngmee Jung, Cho Hay Mun, Ji Heung Kim, Soo Hyun Kim

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Hydrophobicity-enhanced poly(l-lactide-co-ε-caprolactone) (PLCL) (50:50) films were cast by using the solvent-nonsolvent casting method. PLCL (50:50) was synthesized by the well-known random copolymerization process and confirmed by 1 H NMR analysis. The molecular weight of the synthesized PLCL was measured by gel permeation chromatography (GPC). Number-average (Mn), weight-average (Mw) molecular weights and polydispersity (Mw/Mn) were 7 × 10 4 , 1.2 × 10 5 , and 1.7, respectively. PLCL films were cast in vacuum condition with various nonsolvents and nonsolvent ratios. Tetrahydrofuran (THF) was used as the solvent and three different alcohols were used as the nonsolvent: methanol, ethanol, and isopropyl alcohol (IPA). Surface hydrophobicity was confirmed by water contact angle. The water contact angle was increased from 81 ± 2 to 107 ± 2. Water contact angle was influenced by surface porosity and topography. The prepared film surfaces were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The change of crystalline property was characterized by X-ray diffraction (XRD). Platelet adhesion tests on the modified PLCL film surfaces were evaluated by platelet-rich plasma (PRP). The modified film surface exhibited enhanced hydrophobicity and reduced platelet adhesion ratio depending on the surface topography. One of the candidate products proposed as a potential blood compatible material showed a markedly reduced platelet adhesion property.

Original languageEnglish
Pages (from-to)586-591
Number of pages6
JournalApplied Surface Science
Publication statusPublished - 2013 Jul 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (MEST) NRF-2010-C1AAA001-2010-0028939 and the Fundamental Research Program of KIST .


  • Blood
  • Hydrophobicity
  • PLCL
  • Porous material
  • Surface modification
  • compatibility

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics
  • General Physics and Astronomy
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films


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