Preparation of sodium alginate microspheres containing hydrophilic β-lactam antibiotics

Kyung Hee Chun; Ick Chan Kwon; Yong Hee Kim; Sung Bum La; Young Taek Sohn; Seo Young Jeong

doi:10.1007/BF02976843

Preparation of sodium alginate microspheres containing hydrophilic β-lactam antibiotics

Kyung Hee Chun, Ick Chan Kwon, Yong Hee Kim, Sung Bum La, Young Taek Sohn, Seo Young Jeong

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Alginate microspheres were prepared by the emulsification process as a drug delivery system of ampicillin sodium (AMP-Na). The preparation parameters such as the concentration of calcium chloride, the stirring time and the amount of AMP-Na were investigated. The alginate microspheres containing hydroxypropylmethylcellulose (HPMC) were found to be generally spherical, discrete and had smoother surfaces when compared to without HPMC. However, there was no significant difference in the release profile of AMP-Na from alginate microspheres prepared with or without HPMC. The concentration of calcium chloride solution and the stirring time in the preparation of alginate microspheres influenced the aggregation of alginate microspheres. The amount of AMP-Na in alginate microspheres influenced the sur face morphology and the practical drug content in microspheres.

Original language	English
Pages (from-to)	106-111
Number of pages	6
Journal	Archives of pharmacal research
Volume	19
Issue number	2
DOIs	https://doi.org/10.1007/BF02976843
Publication status	Published - 1996

Keywords

Ampicillin sodium
Controlled release
Microspheres
Sodium alginate

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/BF02976843

Cite this

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abstract = "Alginate microspheres were prepared by the emulsification process as a drug delivery system of ampicillin sodium (AMP-Na). The preparation parameters such as the concentration of calcium chloride, the stirring time and the amount of AMP-Na were investigated. The alginate microspheres containing hydroxypropylmethylcellulose (HPMC) were found to be generally spherical, discrete and had smoother surfaces when compared to without HPMC. However, there was no significant difference in the release profile of AMP-Na from alginate microspheres prepared with or without HPMC. The concentration of calcium chloride solution and the stirring time in the preparation of alginate microspheres influenced the aggregation of alginate microspheres. The amount of AMP-Na in alginate microspheres influenced the sur face morphology and the practical drug content in microspheres.",

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AU - Chun, Kyung Hee

AU - Kwon, Ick Chan

AU - Kim, Yong Hee

AU - La, Sung Bum

AU - Sohn, Young Taek

AU - Jeong, Seo Young

PY - 1996

Y1 - 1996

N2 - Alginate microspheres were prepared by the emulsification process as a drug delivery system of ampicillin sodium (AMP-Na). The preparation parameters such as the concentration of calcium chloride, the stirring time and the amount of AMP-Na were investigated. The alginate microspheres containing hydroxypropylmethylcellulose (HPMC) were found to be generally spherical, discrete and had smoother surfaces when compared to without HPMC. However, there was no significant difference in the release profile of AMP-Na from alginate microspheres prepared with or without HPMC. The concentration of calcium chloride solution and the stirring time in the preparation of alginate microspheres influenced the aggregation of alginate microspheres. The amount of AMP-Na in alginate microspheres influenced the sur face morphology and the practical drug content in microspheres.

AB - Alginate microspheres were prepared by the emulsification process as a drug delivery system of ampicillin sodium (AMP-Na). The preparation parameters such as the concentration of calcium chloride, the stirring time and the amount of AMP-Na were investigated. The alginate microspheres containing hydroxypropylmethylcellulose (HPMC) were found to be generally spherical, discrete and had smoother surfaces when compared to without HPMC. However, there was no significant difference in the release profile of AMP-Na from alginate microspheres prepared with or without HPMC. The concentration of calcium chloride solution and the stirring time in the preparation of alginate microspheres influenced the aggregation of alginate microspheres. The amount of AMP-Na in alginate microspheres influenced the sur face morphology and the practical drug content in microspheres.

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Preparation of sodium alginate microspheres containing hydrophilic β-lactam antibiotics

Abstract

Keywords

ASJC Scopus subject areas

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