Abstract
Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.
| Original language | English |
|---|---|
| Pages (from-to) | 1083-1086 |
| Number of pages | 4 |
| Journal | Journal of Pediatric Endocrinology and Metabolism |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2005 Nov |
| Externally published | Yes |
Bibliographical note
Funding Information:This study was supported by a Korea Foundation Grant (KRF-2004-E00111).
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Children
- Ghrelin
- Leu72Met polymorphism
- Obesity
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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