Presence of gonadotropin-releasing hormone mRNA in the rat olfactory piriform cortex

Wan Sung Choi, Myung Ok Kim, Byung Ju Lee, Jin Hyun Kim, Woong Sun, Jae Young Seong, Kyungjin Kim

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Gonadotropin releasing hormone (GnRH) neurons are known to be originated from the olfactory placode and to enter the forebrain regions during embryonic development. The present study aims to ascertain whether GnRH is locally expressed in the olfactory cortex. Northern blot hybridization and reverse transcription-polymerase chain reaction revealed that GnRH mRNA was present in the rat olfactory cortex as well as in the olfactory bulb. The predicted size of GnRH mRNA is similar to that detected in the hypothalamus. In situ hybridization histochemistry also showed that GnRH mRNA is highly concentrated in the olfactory piriform cortex. The present data indicate that GnRH is synthesized in the olfactory piriform cortex.

Original languageEnglish
Pages (from-to)148-151
Number of pages4
JournalBrain Research
Issue number1
Publication statusPublished - 1994 Jun 13
Externally publishedYes

Bibliographical note

Funding Information:
This study was supportedb y a grant of the Genetic EngineeringR esearchProgram from the Ministry of Education of Korean Governmentto BJL and WSC. The authers are grateful to Dr. V.D. Ramirez for critical reading anvda luables uggestion.


  • Extrahypothalmus
  • GnRH mRNA
  • Olfactory piriform cortex

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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