TY - JOUR
T1 - Prevalence and complications of nonsurgical hypoparathyroidism in Korea
T2 - A nationwide cohort study
AU - Kim, Se Hwa
AU - Rhee, Yumie
AU - Kim, Yoo Mee
AU - Won, Young Jun
AU - Noh, Junghyun
AU - Moon, Hyemi
AU - Lee, Juneyoung
AU - Kim, Sin Gon
N1 - Funding Information:
This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KNIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HI17C1926) to SGK.
Publisher Copyright:
© 2020 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2020/5
Y1 - 2020/5
N2 - Objective The risk of complications of nonsurgical hypoparathyroidism in Asia is unclear. We estimated the prevalence and risk of complications in patients with nonsurgical hypoparathyroidism. Methods We performed a retrospective cohort study using a nationwide claims database from 2005 to 2016. Among the entire Korean population, we identified 897 patients diagnosed with nonsurgical hypoparathyroidism during 2005–2015. We selected 210 patients with nonsurgical hypoparathyroidism during 2005–2008 who had no complications at baseline and followed them to 2016. Control subjects (n = 2075) were matched using propensity scores based on age, sex, and comorbid disease with a 1:10 ratio and monitored until 2016. Results The age-standardized prevalence of nonsurgical hypoparathyroidism was 0.2 cases per 100,000 persons in 2005. During a mean follow-up period of 9.5 years, patients with nonsurgical hypoparathyroidism had a higher risk of cardiovascular disease, especially arrhythmia (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.11–3.70) and heart failure (HR, 2.43; 95% CI, 1.22–4.83). The risk of vertebral fracture was higher in patients than in controls (HR, 2.27; 95% CI, 1.09–4.72). Patients had a significantly increased risk of renal disease (HR, 2.57; 95% CI, 1.56–4.21), seizure (HR, 5.74; 95% CI, 3.34–9.86), depression and bipolar disease (HR, 1.82; 95% CI, 1.30–2.56), and cataract (HR, 1.90; 95% CI, 1.30–2.79) compared with controls. Conclusions The prevalence of nonsurgical hypoparathyroidism was very low in Korea but was associated with a higher risk of incident cardiovascular disease and vertebral fracture as well as known complications including renal disease, seizure, and cataract.
AB - Objective The risk of complications of nonsurgical hypoparathyroidism in Asia is unclear. We estimated the prevalence and risk of complications in patients with nonsurgical hypoparathyroidism. Methods We performed a retrospective cohort study using a nationwide claims database from 2005 to 2016. Among the entire Korean population, we identified 897 patients diagnosed with nonsurgical hypoparathyroidism during 2005–2015. We selected 210 patients with nonsurgical hypoparathyroidism during 2005–2008 who had no complications at baseline and followed them to 2016. Control subjects (n = 2075) were matched using propensity scores based on age, sex, and comorbid disease with a 1:10 ratio and monitored until 2016. Results The age-standardized prevalence of nonsurgical hypoparathyroidism was 0.2 cases per 100,000 persons in 2005. During a mean follow-up period of 9.5 years, patients with nonsurgical hypoparathyroidism had a higher risk of cardiovascular disease, especially arrhythmia (hazard ratio [HR], 2.03; 95% confidence interval [CI], 1.11–3.70) and heart failure (HR, 2.43; 95% CI, 1.22–4.83). The risk of vertebral fracture was higher in patients than in controls (HR, 2.27; 95% CI, 1.09–4.72). Patients had a significantly increased risk of renal disease (HR, 2.57; 95% CI, 1.56–4.21), seizure (HR, 5.74; 95% CI, 3.34–9.86), depression and bipolar disease (HR, 1.82; 95% CI, 1.30–2.56), and cataract (HR, 1.90; 95% CI, 1.30–2.79) compared with controls. Conclusions The prevalence of nonsurgical hypoparathyroidism was very low in Korea but was associated with a higher risk of incident cardiovascular disease and vertebral fracture as well as known complications including renal disease, seizure, and cataract.
UR - http://www.scopus.com/inward/record.url?scp=85084352582&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0232842
DO - 10.1371/journal.pone.0232842
M3 - Article
C2 - 32384131
AN - SCOPUS:85084352582
SN - 1932-6203
VL - 15
JO - PLoS One
JF - PLoS One
IS - 5
M1 - e0232842
ER -
