Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: The Korean Health and Genome Study

C. Shin; R. D. Abbott; H. Lee; J. Kim; K. Kimm

doi:10.1038/sj.jhh.1001732

Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: The Korean Health and Genome Study

C. Shin
, R. D. Abbott
, H. Lee
, J. Kim
, K. Kimm^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

118 Citations (Scopus)

Abstract

To examine the prevalence and correlates of orthostatic hypotension (OH) in middle-aged adults enrolled in the Korean Health and Genome Study. Participants were 8908 individuals aged 40-69 years. Supine blood pressure (BP) was measured three times at 30-s intervals after at least 5 min of rest in the supine position and single standing BP was measured at 0 and 2 min after standing, respectively. OH was defined as a reduction in systolic BP or diastolic BP ≥ 20 and 10 mmHg, respectively. The prevalence of OH at 0 and 2 min after standing was 12.3 and 2.9%, respectively. At 0 min of standing, OH frequency increased significantly with age from 6.4% in those aged 40-44 years to 23.1% in those aged 65-69 (P<0.001). After adjustment for age and other characteristics, hypertension was associated with a 1.7-fold excess in the odds of OH in men and a 1.6-fold excess in women (P< 0.001). In contrast, an increase in body mass index (BMI) on the order of 5 kg/m² was associated with a 20-30% reduction in the odds of OH (P<0.001). Diabetes in women was also associated with a 1.4-fold excess in the odds of OH (P<0.05). An increase in triglyceride by 136 mg/dl in men was associated with an increase in the odds of OH (P< 0.05). In conclusion, the prevalence and correlates of OH other than diabetes and triglycerides were notably similar in men and women. While the association between hypertension and OH has been observed elsewhere, low BMI in Korean adults with OH may be an important marker for subclinical morbidity or coexisting risk factors that need to be identified.

Original language	English
Pages (from-to)	717-723
Number of pages	7
Journal	Journal of Human Hypertension
Volume	18
Issue number	10
DOIs	https://doi.org/10.1038/sj.jhh.1001732
Publication status	Published - 2004 Oct

Bibliographical note

Funding Information:
We thank Jung Bok Lee from the Institute of Statistics at Korea University for valuable statistical guidance. The study was supported by a grant from the Korean National Institute of Health (government budget code 348-6111-221).

Funding Information:
Correspondence: Dr K Kimm, Korean National Genome Institute, Korean National Institute of Health, 5 Nok-Bun-Dong, Eun-Pyung-Gu, Seoul 122-701, South Korea. E-mail: [email protected] Supported by a grant from the Korean National Institute of Health (Government budget code 348-6111-221). Received 31 July 2003; revised 16 February 2004; accepted 17 February 2004; published online 29 April 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Blood pressure
Epidemiology
Korea
Orthostatic hypotension

ASJC Scopus subject areas

Internal Medicine

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10.1038/sj.jhh.1001732

Cite this

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title = "Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: The Korean Health and Genome Study",

abstract = "To examine the prevalence and correlates of orthostatic hypotension (OH) in middle-aged adults enrolled in the Korean Health and Genome Study. Participants were 8908 individuals aged 40-69 years. Supine blood pressure (BP) was measured three times at 30-s intervals after at least 5 min of rest in the supine position and single standing BP was measured at 0 and 2 min after standing, respectively. OH was defined as a reduction in systolic BP or diastolic BP ≥ 20 and 10 mmHg, respectively. The prevalence of OH at 0 and 2 min after standing was 12.3 and 2.9\%, respectively. At 0 min of standing, OH frequency increased significantly with age from 6.4\% in those aged 40-44 years to 23.1\% in those aged 65-69 (P<0.001). After adjustment for age and other characteristics, hypertension was associated with a 1.7-fold excess in the odds of OH in men and a 1.6-fold excess in women (P< 0.001). In contrast, an increase in body mass index (BMI) on the order of 5 kg/m2 was associated with a 20-30\% reduction in the odds of OH (P<0.001). Diabetes in women was also associated with a 1.4-fold excess in the odds of OH (P<0.05). An increase in triglyceride by 136 mg/dl in men was associated with an increase in the odds of OH (P< 0.05). In conclusion, the prevalence and correlates of OH other than diabetes and triglycerides were notably similar in men and women. While the association between hypertension and OH has been observed elsewhere, low BMI in Korean adults with OH may be an important marker for subclinical morbidity or coexisting risk factors that need to be identified.",

keywords = "Blood pressure, Epidemiology, Korea, Orthostatic hypotension",

author = "C. Shin and Abbott, \{R. D.\} and H. Lee and J. Kim and K. Kimm",

note = "Funding Information: We thank Jung Bok Lee from the Institute of Statistics at Korea University for valuable statistical guidance. The study was supported by a grant from the Korean National Institute of Health (government budget code 348-6111-221). Funding Information: Correspondence: Dr K Kimm, Korean National Genome Institute, Korean National Institute of Health, 5 Nok-Bun-Dong, Eun-Pyung-Gu, Seoul 122-701, South Korea. E-mail: [email protected] Supported by a grant from the Korean National Institute of Health (Government budget code 348-6111-221). Received 31 July 2003; revised 16 February 2004; accepted 17 February 2004; published online 29 April 2004",

year = "2004",

month = oct,

doi = "10.1038/sj.jhh.1001732",

language = "English",

volume = "18",

pages = "717--723",

journal = "Journal of Human Hypertension",

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T2 - The Korean Health and Genome Study

AU - Shin, C.

AU - Abbott, R. D.

AU - Lee, H.

AU - Kim, J.

AU - Kimm, K.

N1 - Funding Information: We thank Jung Bok Lee from the Institute of Statistics at Korea University for valuable statistical guidance. The study was supported by a grant from the Korean National Institute of Health (government budget code 348-6111-221). Funding Information: Correspondence: Dr K Kimm, Korean National Genome Institute, Korean National Institute of Health, 5 Nok-Bun-Dong, Eun-Pyung-Gu, Seoul 122-701, South Korea. E-mail: [email protected] Supported by a grant from the Korean National Institute of Health (Government budget code 348-6111-221). Received 31 July 2003; revised 16 February 2004; accepted 17 February 2004; published online 29 April 2004

PY - 2004/10

Y1 - 2004/10

N2 - To examine the prevalence and correlates of orthostatic hypotension (OH) in middle-aged adults enrolled in the Korean Health and Genome Study. Participants were 8908 individuals aged 40-69 years. Supine blood pressure (BP) was measured three times at 30-s intervals after at least 5 min of rest in the supine position and single standing BP was measured at 0 and 2 min after standing, respectively. OH was defined as a reduction in systolic BP or diastolic BP ≥ 20 and 10 mmHg, respectively. The prevalence of OH at 0 and 2 min after standing was 12.3 and 2.9%, respectively. At 0 min of standing, OH frequency increased significantly with age from 6.4% in those aged 40-44 years to 23.1% in those aged 65-69 (P<0.001). After adjustment for age and other characteristics, hypertension was associated with a 1.7-fold excess in the odds of OH in men and a 1.6-fold excess in women (P< 0.001). In contrast, an increase in body mass index (BMI) on the order of 5 kg/m2 was associated with a 20-30% reduction in the odds of OH (P<0.001). Diabetes in women was also associated with a 1.4-fold excess in the odds of OH (P<0.05). An increase in triglyceride by 136 mg/dl in men was associated with an increase in the odds of OH (P< 0.05). In conclusion, the prevalence and correlates of OH other than diabetes and triglycerides were notably similar in men and women. While the association between hypertension and OH has been observed elsewhere, low BMI in Korean adults with OH may be an important marker for subclinical morbidity or coexisting risk factors that need to be identified.

AB - To examine the prevalence and correlates of orthostatic hypotension (OH) in middle-aged adults enrolled in the Korean Health and Genome Study. Participants were 8908 individuals aged 40-69 years. Supine blood pressure (BP) was measured three times at 30-s intervals after at least 5 min of rest in the supine position and single standing BP was measured at 0 and 2 min after standing, respectively. OH was defined as a reduction in systolic BP or diastolic BP ≥ 20 and 10 mmHg, respectively. The prevalence of OH at 0 and 2 min after standing was 12.3 and 2.9%, respectively. At 0 min of standing, OH frequency increased significantly with age from 6.4% in those aged 40-44 years to 23.1% in those aged 65-69 (P<0.001). After adjustment for age and other characteristics, hypertension was associated with a 1.7-fold excess in the odds of OH in men and a 1.6-fold excess in women (P< 0.001). In contrast, an increase in body mass index (BMI) on the order of 5 kg/m2 was associated with a 20-30% reduction in the odds of OH (P<0.001). Diabetes in women was also associated with a 1.4-fold excess in the odds of OH (P<0.05). An increase in triglyceride by 136 mg/dl in men was associated with an increase in the odds of OH (P< 0.05). In conclusion, the prevalence and correlates of OH other than diabetes and triglycerides were notably similar in men and women. While the association between hypertension and OH has been observed elsewhere, low BMI in Korean adults with OH may be an important marker for subclinical morbidity or coexisting risk factors that need to be identified.

KW - Blood pressure

KW - Epidemiology

KW - Korea

KW - Orthostatic hypotension

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M3 - Article

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AN - SCOPUS:5644254813

SN - 0950-9240

VL - 18

SP - 717

EP - 723

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

IS - 10

ER -

Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: The Korean Health and Genome Study

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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