Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: Emergence of a novel OXA-182

Chang Ki Kim; Yangsoon Lee; Hyukmin Lee; Gun Jo Woo; Wonkeun Song; Mi Na Kim; Wee Gyo Lee; Seok Hoon Jeong; Kyungwon Lee; Yunsop Chong

doi:10.1016/j.diagmicrobio.2010.07.014

Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: Emergence of a novel OXA-182

Chang Ki Kim, Yangsoon Lee, Hyukmin Lee, Gun Jo Woo, Wonkeun Song, Mi Na Kim, Wee Gyo Lee, Seok Hoon Jeong, Kyungwon Lee, Yunsop Chong

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. bla_OXA-23-like and ISAba1-asssociated bla_OXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel bla_OXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with bla_OXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.

Original language	English
Pages (from-to)	432-438
Number of pages	7
Journal	Diagnostic Microbiology and Infectious Disease
Volume	68
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2010.07.014
Publication status	Published - 2010 Dec

Keywords

Acinetobacter baumannii
Acinetobacter genomospecies
Korea
Metallo-?-lactamase
OXA carbapenemase
OXA-182

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2010.07.014

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@article{83bbab002cff4af58a6775b3b803e400,

title = "Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: Emergence of a novel OXA-182",

abstract = "Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.",

keywords = "Acinetobacter baumannii, Acinetobacter genomospecies, Korea, Metallo-?-lactamase, OXA carbapenemase, OXA-182",

author = "Kim, {Chang Ki} and Yangsoon Lee and Hyukmin Lee and Woo, {Gun Jo} and Wonkeun Song and Kim, {Mi Na} and Lee, {Wee Gyo} and Jeong, {Seok Hoon} and Kyungwon Lee and Yunsop Chong",

note = "Funding Information: This study was supported in part by grant S-07-02-2-ABI-174-0-T from the Korea Food and Drug Administration in 2007, Republic of Korea. ",

year = "2010",

month = dec,

doi = "10.1016/j.diagmicrobio.2010.07.014",

language = "English",

volume = "68",

pages = "432--438",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea

T2 - Emergence of a novel OXA-182

AU - Kim, Chang Ki

AU - Lee, Yangsoon

AU - Lee, Hyukmin

AU - Woo, Gun Jo

AU - Song, Wonkeun

AU - Kim, Mi Na

AU - Lee, Wee Gyo

AU - Jeong, Seok Hoon

AU - Lee, Kyungwon

AU - Chong, Yunsop

N1 - Funding Information: This study was supported in part by grant S-07-02-2-ABI-174-0-T from the Korea Food and Drug Administration in 2007, Republic of Korea.

PY - 2010/12

Y1 - 2010/12

N2 - Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.

AB - Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.

KW - Acinetobacter baumannii

KW - Acinetobacter genomospecies

KW - Korea

KW - Metallo-?-lactamase

KW - OXA carbapenemase

KW - OXA-182

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U2 - 10.1016/j.diagmicrobio.2010.07.014

DO - 10.1016/j.diagmicrobio.2010.07.014

M3 - Article

C2 - 20884158

AN - SCOPUS:78649265630

SN - 0732-8893

VL - 68

SP - 432

EP - 438

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 4

ER -

Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: Emergence of a novel OXA-182

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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