Abstract
Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.
Original language | English |
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Pages (from-to) | 432-438 |
Number of pages | 7 |
Journal | Diagnostic Microbiology and Infectious Disease |
Volume | 68 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2010 Dec |
Keywords
- Acinetobacter baumannii
- Acinetobacter genomospecies
- Korea
- Metallo-?-lactamase
- OXA carbapenemase
- OXA-182
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases