Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: Emergence of a novel OXA-182

Chang Ki Kim; Yangsoon Lee; Hyukmin Lee; Gun Jo Woo; Wonkeun Song; Mi Na Kim; Wee Gyo Lee; Seok Hoon Jeong; Kyungwon Lee; Yunsop Chong

doi:10.1016/j.diagmicrobio.2010.07.014

Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: Emergence of a novel OXA-182

Chang Ki Kim, Yangsoon Lee, Hyukmin Lee, Gun Jo Woo, Wonkeun Song, Mi Na Kim, Wee Gyo Lee, Seok Hoon Jeong, Kyungwon Lee, Yunsop Chong

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. bla_OXA-23-like and ISAba1-asssociated bla_OXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel bla_OXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with bla_OXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.

Original language	English
Pages (from-to)	432-438
Number of pages	7
Journal	Diagnostic Microbiology and Infectious Disease
Volume	68
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2010.07.014
Publication status	Published - 2010 Dec

Bibliographical note

Funding Information:
This study was supported in part by grant S-07-02-2-ABI-174-0-T from the Korea Food and Drug Administration in 2007, Republic of Korea.

Keywords

Acinetobacter baumannii
Acinetobacter genomospecies
Korea
Metallo-?-lactamase
OXA carbapenemase
OXA-182

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2010.07.014

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@article{83bbab002cff4af58a6775b3b803e400,

title = "Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: Emergence of a novel OXA-182",

abstract = "Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.",

keywords = "Acinetobacter baumannii, Acinetobacter genomospecies, Korea, Metallo-?-lactamase, OXA carbapenemase, OXA-182",

author = "Kim, {Chang Ki} and Yangsoon Lee and Hyukmin Lee and Woo, {Gun Jo} and Wonkeun Song and Kim, {Mi Na} and Lee, {Wee Gyo} and Jeong, {Seok Hoon} and Kyungwon Lee and Yunsop Chong",

note = "Funding Information: This study was supported in part by grant S-07-02-2-ABI-174-0-T from the Korea Food and Drug Administration in 2007, Republic of Korea. ",

year = "2010",

month = dec,

doi = "10.1016/j.diagmicrobio.2010.07.014",

language = "English",

volume = "68",

pages = "432--438",

journal = "Diagnostic Microbiology and Infectious Disease",

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T1 - Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea

T2 - Emergence of a novel OXA-182

AU - Kim, Chang Ki

AU - Lee, Yangsoon

AU - Lee, Hyukmin

AU - Woo, Gun Jo

AU - Song, Wonkeun

AU - Kim, Mi Na

AU - Lee, Wee Gyo

AU - Jeong, Seok Hoon

AU - Lee, Kyungwon

AU - Chong, Yunsop

N1 - Funding Information: This study was supported in part by grant S-07-02-2-ABI-174-0-T from the Korea Food and Drug Administration in 2007, Republic of Korea.

PY - 2010/12

Y1 - 2010/12

N2 - Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.

AB - Increase in multidrug-resistant Acinetobacter poses a serious problem in Korea. In this study, 190 imipenem (IPM)-nonsusceptible (NS) Acinetobacter isolates from 12 Korean hospitals in 2007 were used to determine species, prevalence, and antimicrobial susceptibility of OXA carbapenemase- and metallo-?-lactamase (MBL)-producing isolates. blaOXA-23-like and ISAba1-asssociated blaOXA-51-like genes were detected in 80% and 12% of 178 IPM-NS Acinetobacter baumannii isolates, respectively. A novel blaOXA-182 was detected in 12 IPM-NS A. baumannii isolates. Twelve out of 14 MBL-producing isolates were non-baumannii Acinetobacter. A. baumannii isolates with OXA carbapenemase were more often resistant to aminoglycosides, ciprofloxacin, and tigecycline than non-baumannii Acinetobacter isolates with MBL. Identical pulsed- field gel electrophoresis patterns were observed in 89% of A. baumannii isolates with blaOXA-23-like gene. In conclusion, extremely rapid increase of IPM-NS A. baumannii in previous Korean studies was mainly due to clonal spread of OXA-23-producing A. baumannii isolates. A novel OXA-182 emerged in Korea.

KW - Acinetobacter baumannii

KW - Acinetobacter genomospecies

KW - Korea

KW - Metallo-?-lactamase

KW - OXA carbapenemase

KW - OXA-182

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U2 - 10.1016/j.diagmicrobio.2010.07.014

DO - 10.1016/j.diagmicrobio.2010.07.014

M3 - Article

C2 - 20884158

AN - SCOPUS:78649265630

SN - 0732-8893

VL - 68

SP - 432

EP - 438

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 4

ER -

Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: Emergence of a novel OXA-182

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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