Prevalence and incidence of neuromyelitis optica spectrum disorder in Korea: Population based study

Hye Lim Lee, Jae Young Kim, Jin Myoung Seok, Yoon Ho Hong, Nam Gu Lim, Ha Young Shin, Byung Jo Kim, Soon Young Hwang, Ju Hong Min, Byoung Joon Kim

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)


    Background: Although neuromyelitis optica spectrum disorder (NMOSD) is known to be a rare disease, its prevalence and incidence have not yet been studied in Korea. We performed a population-based study to examine the prevalence and incidence of NMOSD in Korea using data from the Korean National Health Insurance (NHI) claims database. Methods: Data from 2013 to 2017 were obtained, with a washout period set as 2013 and 2014. The prevalence and incidence of NMOSD in 2016 and 2017 were calculated using population census data. Subjects were divided into 5 groups at 15-year intervals, depending on the age at which the diagnostic code was entered. The relative risk (RR) for each age group was compared with the oldest (≥ 60 years) age group. Results: The overall prevalence was estimated to be 3.36 and 3.56 per 100,000 individuals, with an incidence of 0.41 and 0.65 per 100,000 individuals-year in 2016 and 2017, respectively. The mean age was 43.08 (standard deviation, 14.56) years, and the ratio of male to females was 1:4.7. The incidence was higher in female individuals aged between 30 and 59 years (RR, 2.8-3.05; P < 0.05). Conclusion: This is the study to investigate the prevalence and incidence of NMOSD using the NHI database. NMOSD was demonstrated to be a very rare disease in Korea.

    Original languageEnglish
    Article numberE115
    JournalJournal of Korean medical science
    Issue number17
    Publication statusPublished - 2020 Mar 4

    Bibliographical note

    Funding Information:
    This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant No. HC17C0078).

    Publisher Copyright:
    © 2020 Korean Academy of Medical Science.


    • Incidence
    • NMOSD
    • Neuromyelitis optica spectrum disorder
    • Prevalence

    ASJC Scopus subject areas

    • General Medicine


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