Prevalence of C-C chemokine receptor type 5 tropism among human immunodeficiency virus 1–infected patients in South Korea

Je Eun Song, Mi Young Ahn, Woo Joo Kim, Shin Woo Kim, Jin Soo Lee, Nam Su Ku, Joon Hyung Kim, Ki Hyon Kim, Heawon Ann, Jun Yong Choi

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: The discovery of two main coreceptors for human immunodeficiency virus (HIV), C-C chemokine receptor type 5 (CCR5), and C-X-C chemokine receptor type 4 has led to a better understanding of the interaction between HIV envelope and host cells, and development of new therapeutic approaches. The purpose of this study was to estimate the prevalence of CCR5 tropism among HIV-1–infected Koreans and identify the predictors for CCR5 tropism. Methods: We enrolled 250 HIV-1–infected subjects from four medical centers of three different cities in South Korea between April 2013 and May 2014. Genotypic assay for identifying coreceptor tropism of HIV-1 was performed with HIV RNA or HIV DNA. Nested polymerase chain reaction and population-based sequencing for the V3 region (HXB2 position 6225-7758) of the envelope were performed with HIV RNA or proviral DNA. Proviral DNA was used if the viral load of the subject was below 2000 copies/mL. Genotypic tropism was determined by a web-based bioinformatics tool (http://coreceptor.bioinf.mpi-inf.mpg.de/). Results: Among 250 individuals enrolled, only 143 subjects could be analyzed for genotypic tropism assay with HIV RNA or proviral DNA. The prevalence of CCR5 tropism was 69.2% (N = 99). We could not identify any significant clinical or epidemiological predictors for CCR5 tropism among enrolled subjects. Conclusions: The prevalence of CCR5 tropism in HIV-1–infected Korean individuals was 69.2%. Since we cannot predict coreceptor tropism by clinical factors, tropism assay should be performed before treatment with the CCR5 antagonist.

    Original languageEnglish
    Pages (from-to)1720-1723
    Number of pages4
    JournalJournal of Medical Virology
    Volume90
    Issue number11
    DOIs
    Publication statusPublished - 2018 Nov

    Bibliographical note

    Publisher Copyright:
    © 2018 Wiley Periodicals, Inc.

    Keywords

    • antiretrovirus drug
    • human immunodeficiency virus
    • receptor

    ASJC Scopus subject areas

    • Infectious Diseases
    • Virology

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