Primary effusion lymphoma with biphenotypic and bigenotypic features of T-cell receptor and IGH genes in an HIV-negative patient with kidney transplant

Taesung Jeon; Young Hyeh Ko; You Na Sung; Hyunsung Kim; Ka Won Kang; Jong Min Sim; Yeseul Kim

doi:10.1007/s00277-025-06396-w

Primary effusion lymphoma with biphenotypic and bigenotypic features of T-cell receptor and IGH genes in an HIV-negative patient with kidney transplant

Taesung Jeon
, Young Hyeh Ko
, You Na Sung
, Hyunsung Kim
, Ka Won Kang
, Jong Min Sim
, Yeseul Kim^*

^*Corresponding author for this work

Department of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Primary effusion lymphoma typically lacks B-cell markers but involves immunoglobulin gene rearrangements, indicating a B-cell origin. This case highlights the unusual co-expression of T-cell antigens and clonal gene rearrangements for both T- and B-cell lineages in PEL. The findings underscore the complex lineage infidelity in PEL, making diagnosis challenging.

Original language	English
Pages (from-to)	5513-5519
Number of pages	7
Journal	Annals of Hematology
Volume	104
Issue number	10
DOIs	https://doi.org/10.1007/s00277-025-06396-w
Publication status	Published - 2025 Oct

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bigenotypic
Biphenotypic
EBV-positive
HIV-negative
Lineage infidelity
Primary effusion lymphoma

ASJC Scopus subject areas

Hematology

Access to Document

10.1007/s00277-025-06396-w

Cite this

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title = "Primary effusion lymphoma with biphenotypic and bigenotypic features of T-cell receptor and IGH genes in an HIV-negative patient with kidney transplant",

abstract = "Primary effusion lymphoma typically lacks B-cell markers but involves immunoglobulin gene rearrangements, indicating a B-cell origin. This case highlights the unusual co-expression of T-cell antigens and clonal gene rearrangements for both T- and B-cell lineages in PEL. The findings underscore the complex lineage infidelity in PEL, making diagnosis challenging.",

keywords = "Bigenotypic, Biphenotypic, EBV-positive, HIV-negative, Lineage infidelity, Primary effusion lymphoma",

author = "Taesung Jeon and Ko, \{Young Hyeh\} and Sung, \{You Na\} and Hyunsung Kim and Kang, \{Ka Won\} and Sim, \{Jong Min\} and Yeseul Kim",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = oct,

doi = "10.1007/s00277-025-06396-w",

language = "English",

volume = "104",

pages = "5513--5519",

journal = "Annals of Hematology",

issn = "0939-5555",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "10",

}

TY - JOUR

T1 - Primary effusion lymphoma with biphenotypic and bigenotypic features of T-cell receptor and IGH genes in an HIV-negative patient with kidney transplant

AU - Jeon, Taesung

AU - Ko, Young Hyeh

AU - Sung, You Na

AU - Kim, Hyunsung

AU - Kang, Ka Won

AU - Sim, Jong Min

AU - Kim, Yeseul

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/10

Y1 - 2025/10

N2 - Primary effusion lymphoma typically lacks B-cell markers but involves immunoglobulin gene rearrangements, indicating a B-cell origin. This case highlights the unusual co-expression of T-cell antigens and clonal gene rearrangements for both T- and B-cell lineages in PEL. The findings underscore the complex lineage infidelity in PEL, making diagnosis challenging.

AB - Primary effusion lymphoma typically lacks B-cell markers but involves immunoglobulin gene rearrangements, indicating a B-cell origin. This case highlights the unusual co-expression of T-cell antigens and clonal gene rearrangements for both T- and B-cell lineages in PEL. The findings underscore the complex lineage infidelity in PEL, making diagnosis challenging.

KW - Bigenotypic

KW - Biphenotypic

KW - EBV-positive

KW - HIV-negative

KW - Lineage infidelity

KW - Primary effusion lymphoma

UR - https://www.scopus.com/pages/publications/105016730403

U2 - 10.1007/s00277-025-06396-w

DO - 10.1007/s00277-025-06396-w

M3 - Article

C2 - 40970925

AN - SCOPUS:105016730403

SN - 0939-5555

VL - 104

SP - 5513

EP - 5519

JO - Annals of Hematology

JF - Annals of Hematology

IS - 10

ER -

Primary effusion lymphoma with biphenotypic and bigenotypic features of T-cell receptor and IGH genes in an HIV-negative patient with kidney transplant

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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