Primary hepatic marginal zone B cell lymphoma: A case report and review of the literature

Young Dong Yu, Dong Sik Kim, Geon Young Byun, Jeong Hyeon Lee, In Sun Kim, Chung Yun Kim, Young Chul Kim, Sung Ock Suh

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15 Citations (Scopus)


Background Primary hepatic lymphoma (PHL) is a very rare malignancy, and constitutes about 0.016% of all cases of non-Hodgkin's lymphoma and is often misdiagnosed. The optimal therapy is still unclear and the outcomes are uncertain. Among PHLs, a primary hepatic low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is extremely rare. Methods We present a case of primary hepatic lymphoma (MALT lymphoma) treated with surgical resection and adjuvant chemotherapy. A 38-year-old Korean man, who was diagnosed with chronic hepatitis B 20 years ago, was admitted for liver biopsy after liver lesions were detected on follow-up computed tomography scan (CT). Liver biopsy revealed the diagnosis of marginal zone B-cell malignant lymphoma (MALT lymphoma). The preoperative clinical staging was IE, given that no additional foci of lymphoma were found anywhere else in the body. The patient underwent left hemihepatectomy. Subsequently, the patient received two cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) regimen. Results After 15 months of follow-up, the patient is alive and well without any evidence of disease recurrence. Conclusion Although the prognosis is variable, good response to early surgery combined with postoperative chemotherapy can be achieved in strictly selected patients.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalIndian Journal of Surgery
Issue number1 SUPPL.
Publication statusPublished - 2013 Oct
Externally publishedYes


  • Adjuvant chemotherapy
  • Chronic hepatitis B
  • MALT lymphoma
  • Primary hepatic lymphoma
  • Surgery

ASJC Scopus subject areas

  • Surgery


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