Production of penicillic acid by Aspergillus sclerotiorum CGF

S. W. Kang; C. H. Park; S. I. Hong; S. W. Kim

doi:10.1016/j.biortech.2005.11.033

Production of penicillic acid by Aspergillus sclerotiorum CGF

S. W. Kang
, C. H. Park
, S. I. Hong
, S. W. Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The production of penicillic acid by Aspergillus sclerotiorum CGF for the biocontrol of Phytophthora disease was investigated in submerged fermentation using media composed of different nutrients. Soluble starch was found to be the most effective substrate among the carbon sources used, and produced the highest penicillic acid concentration of 2.98 mg ml^-1. When organic nitrogen sources were used, pharmamedia, yeast extract, and polypeptone-S were found to be suitable organic nitrogen sources (2.46-2.71 mg ml^-1). The production of penicillic acid was not detected in when inorganic nitrogen sources were used. Only Na₂HPO₄, among the metal ions and phosphate salts tested, increased the production of penicillic acid (≈20%). When A. sclerotiorum CGF was cultured in optimal medium [8.0% (w/v) soluble starch, 0.6% (w/v) yeast extract, and 0.3% (w/v) Na₂HPO₄], maximum penicillic acid concentration (≈9.40 mg ml^-1) and cell mass (≈17.4 g l^-1) were obtained after 12 days.

Original language	English
Pages (from-to)	191-197
Number of pages	7
Journal	Bioresource technology
Volume	98
Issue number	1
DOIs	https://doi.org/10.1016/j.biortech.2005.11.033
Publication status	Published - 2007 Jan

Bibliographical note

Funding Information:
This study was supported by research grants from the Korea Science and Engineering Foundation (KOSEF) through the Applied Rheology Center (ARC), an official KOSEF-created engineering research center (ERC) at Korea University, Seoul, Korea.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy

Keywords

Aspergillus sclerotiorum
Penicillic acid
Phytophthora species
Submerged fermentation

ASJC Scopus subject areas

Bioengineering
Environmental Engineering
Renewable Energy, Sustainability and the Environment
Waste Management and Disposal

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10.1016/j.biortech.2005.11.033

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title = "Production of penicillic acid by Aspergillus sclerotiorum CGF",

abstract = "The production of penicillic acid by Aspergillus sclerotiorum CGF for the biocontrol of Phytophthora disease was investigated in submerged fermentation using media composed of different nutrients. Soluble starch was found to be the most effective substrate among the carbon sources used, and produced the highest penicillic acid concentration of 2.98 mg ml-1. When organic nitrogen sources were used, pharmamedia, yeast extract, and polypeptone-S were found to be suitable organic nitrogen sources (2.46-2.71 mg ml-1). The production of penicillic acid was not detected in when inorganic nitrogen sources were used. Only Na2HPO4, among the metal ions and phosphate salts tested, increased the production of penicillic acid (≈20\%). When A. sclerotiorum CGF was cultured in optimal medium [8.0\% (w/v) soluble starch, 0.6\% (w/v) yeast extract, and 0.3\% (w/v) Na2HPO4], maximum penicillic acid concentration (≈9.40 mg ml-1) and cell mass (≈17.4 g l-1) were obtained after 12 days.",

keywords = "Aspergillus sclerotiorum, Penicillic acid, Phytophthora species, Submerged fermentation",

author = "Kang, \{S. W.\} and Park, \{C. H.\} and Hong, \{S. I.\} and Kim, \{S. W.\}",

note = "Funding Information: This study was supported by research grants from the Korea Science and Engineering Foundation (KOSEF) through the Applied Rheology Center (ARC), an official KOSEF-created engineering research center (ERC) at Korea University, Seoul, Korea.",

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doi = "10.1016/j.biortech.2005.11.033",

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pages = "191--197",

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AU - Kang, S. W.

AU - Park, C. H.

AU - Hong, S. I.

AU - Kim, S. W.

N1 - Funding Information: This study was supported by research grants from the Korea Science and Engineering Foundation (KOSEF) through the Applied Rheology Center (ARC), an official KOSEF-created engineering research center (ERC) at Korea University, Seoul, Korea.

PY - 2007/1

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N2 - The production of penicillic acid by Aspergillus sclerotiorum CGF for the biocontrol of Phytophthora disease was investigated in submerged fermentation using media composed of different nutrients. Soluble starch was found to be the most effective substrate among the carbon sources used, and produced the highest penicillic acid concentration of 2.98 mg ml-1. When organic nitrogen sources were used, pharmamedia, yeast extract, and polypeptone-S were found to be suitable organic nitrogen sources (2.46-2.71 mg ml-1). The production of penicillic acid was not detected in when inorganic nitrogen sources were used. Only Na2HPO4, among the metal ions and phosphate salts tested, increased the production of penicillic acid (≈20%). When A. sclerotiorum CGF was cultured in optimal medium [8.0% (w/v) soluble starch, 0.6% (w/v) yeast extract, and 0.3% (w/v) Na2HPO4], maximum penicillic acid concentration (≈9.40 mg ml-1) and cell mass (≈17.4 g l-1) were obtained after 12 days.

AB - The production of penicillic acid by Aspergillus sclerotiorum CGF for the biocontrol of Phytophthora disease was investigated in submerged fermentation using media composed of different nutrients. Soluble starch was found to be the most effective substrate among the carbon sources used, and produced the highest penicillic acid concentration of 2.98 mg ml-1. When organic nitrogen sources were used, pharmamedia, yeast extract, and polypeptone-S were found to be suitable organic nitrogen sources (2.46-2.71 mg ml-1). The production of penicillic acid was not detected in when inorganic nitrogen sources were used. Only Na2HPO4, among the metal ions and phosphate salts tested, increased the production of penicillic acid (≈20%). When A. sclerotiorum CGF was cultured in optimal medium [8.0% (w/v) soluble starch, 0.6% (w/v) yeast extract, and 0.3% (w/v) Na2HPO4], maximum penicillic acid concentration (≈9.40 mg ml-1) and cell mass (≈17.4 g l-1) were obtained after 12 days.

KW - Aspergillus sclerotiorum

KW - Penicillic acid

KW - Phytophthora species

KW - Submerged fermentation

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Production of penicillic acid by Aspergillus sclerotiorum CGF

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

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