Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction

Young Joon Hong; Myung Ho Jeong; Dae Woo Hyun; Seung Ho Hur; Kwon Bae Kim; Weon Kim; Sang Yup Lim; Sang Hyun Lee; Seo Na Hong; Dong Goo Kang; Kyung Ho Yun; Kye Hun Kim; Yun Sang Lee; Hyung Wook Park; Ju Han Kim; Young Keun Ahn; Jeong Gwan Cho; Jong Chun Park; Jung Chaee Kang

doi:10.1016/j.amjcard.2004.10.039

Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction

Young Joon Hong, Myung Ho Jeong, Dae Woo Hyun, Seung Ho Hur, Kwon Bae Kim, Weon Kim, Sang Yup Lim, Sang Hyun Lee, Seo Na Hong, Dong Goo Kang, Kyung Ho Yun, Kye Hun Kim, Yun Sang Lee, Hyung Wook Park, Ju Han Kim, Young Keun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

We prospectively followed 202 patients with ischemic heart failure who underwent percutaneous coronary intervention (PCI) for acute myocardial infarction (left ventricular [LV] ejection fraction <40%). Patients were divided into 2 groups: groups I (simvastatin group, n = 106, aged 60.8 ± 10.3 years, men 71.7%) and II (non-simvastatin group, n = 96, aged 60.9 ± 10.4 years, men 78.1%). During 1-year clinical follow-up, simvastatin therapy was associated with a significant reduction in mortality (1.9% vs 7.5%, p = 0.048), restenosis rate (25.7% vs 43.1%, p = 0.033), and repeat PCI rate (25.7% vs 43.1%, p = 0.033), and with significant improvement in LV ejection fraction (31% to 42% vs 32% to 39%, p = 0.042). The event-free survival rate was higher in group I than in group II (79.8% vs 57.0%, p = 0.001). In conclusion, simvastatin therapy improves LV systolic function and decreases mortality, restenosis, and repeat PCI rate in patients with ischemic heart failure who underwent PCI for acute myocardial infarction.

Original language	English
Pages (from-to)	619-622
Number of pages	4
Journal	American Journal of Cardiology
Volume	95
Issue number	5
DOIs	https://doi.org/10.1016/j.amjcard.2004.10.039
Publication status	Published - 2005 Mar 1
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.amjcard.2004.10.039

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Hong, Y. J., Jeong, M. H., Hyun, D. W., Hur, S. H., Kim, K. B., Kim, W., Lim, S. Y., Lee, S. H., Hong, S. N., Kang, D. G., Yun, K. H., Kim, K. H., Lee, Y. S., Park, H. W., Kim, J. H., Ahn, Y. K., Cho, J. G., Park, J. C., & Kang, J. C. (2005). Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction. American Journal of Cardiology, 95(5), 619-622. https://doi.org/10.1016/j.amjcard.2004.10.039

Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction. / Hong, Young Joon; Jeong, Myung Ho; Hyun, Dae Woo et al.
In: American Journal of Cardiology, Vol. 95, No. 5, 01.03.2005, p. 619-622.

Research output: Contribution to journal › Article › peer-review

Hong, YJ, Jeong, MH, Hyun, DW, Hur, SH, Kim, KB, Kim, W, Lim, SY, Lee, SH, Hong, SN, Kang, DG, Yun, KH, Kim, KH, Lee, YS, Park, HW, Kim, JH, Ahn, YK, Cho, JG, Park, JC & Kang, JC 2005, 'Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction', American Journal of Cardiology, vol. 95, no. 5, pp. 619-622. https://doi.org/10.1016/j.amjcard.2004.10.039

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title = "Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction",

abstract = "We prospectively followed 202 patients with ischemic heart failure who underwent percutaneous coronary intervention (PCI) for acute myocardial infarction (left ventricular [LV] ejection fraction <40%). Patients were divided into 2 groups: groups I (simvastatin group, n = 106, aged 60.8 ± 10.3 years, men 71.7%) and II (non-simvastatin group, n = 96, aged 60.9 ± 10.4 years, men 78.1%). During 1-year clinical follow-up, simvastatin therapy was associated with a significant reduction in mortality (1.9% vs 7.5%, p = 0.048), restenosis rate (25.7% vs 43.1%, p = 0.033), and repeat PCI rate (25.7% vs 43.1%, p = 0.033), and with significant improvement in LV ejection fraction (31% to 42% vs 32% to 39%, p = 0.042). The event-free survival rate was higher in group I than in group II (79.8% vs 57.0%, p = 0.001). In conclusion, simvastatin therapy improves LV systolic function and decreases mortality, restenosis, and repeat PCI rate in patients with ischemic heart failure who underwent PCI for acute myocardial infarction.",

author = "Hong, {Young Joon} and Jeong, {Myung Ho} and Hyun, {Dae Woo} and Hur, {Seung Ho} and Kim, {Kwon Bae} and Weon Kim and Lim, {Sang Yup} and Lee, {Sang Hyun} and Hong, {Seo Na} and Kang, {Dong Goo} and Yun, {Kyung Ho} and Kim, {Kye Hun} and Lee, {Yun Sang} and Park, {Hyung Wook} and Kim, {Ju Han} and Ahn, {Young Keun} and Cho, {Jeong Gwan} and Park, {Jong Chun} and Kang, {Jung Chaee}",

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doi = "10.1016/j.amjcard.2004.10.039",

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AU - Hong, Young Joon

AU - Jeong, Myung Ho

AU - Hyun, Dae Woo

AU - Hur, Seung Ho

AU - Kim, Kwon Bae

AU - Kim, Weon

AU - Lim, Sang Yup

AU - Lee, Sang Hyun

AU - Hong, Seo Na

AU - Kang, Dong Goo

AU - Yun, Kyung Ho

AU - Kim, Kye Hun

AU - Lee, Yun Sang

AU - Park, Hyung Wook

AU - Kim, Ju Han

AU - Ahn, Young Keun

AU - Cho, Jeong Gwan

AU - Park, Jong Chun

AU - Kang, Jung Chaee

PY - 2005/3/1

Y1 - 2005/3/1

N2 - We prospectively followed 202 patients with ischemic heart failure who underwent percutaneous coronary intervention (PCI) for acute myocardial infarction (left ventricular [LV] ejection fraction <40%). Patients were divided into 2 groups: groups I (simvastatin group, n = 106, aged 60.8 ± 10.3 years, men 71.7%) and II (non-simvastatin group, n = 96, aged 60.9 ± 10.4 years, men 78.1%). During 1-year clinical follow-up, simvastatin therapy was associated with a significant reduction in mortality (1.9% vs 7.5%, p = 0.048), restenosis rate (25.7% vs 43.1%, p = 0.033), and repeat PCI rate (25.7% vs 43.1%, p = 0.033), and with significant improvement in LV ejection fraction (31% to 42% vs 32% to 39%, p = 0.042). The event-free survival rate was higher in group I than in group II (79.8% vs 57.0%, p = 0.001). In conclusion, simvastatin therapy improves LV systolic function and decreases mortality, restenosis, and repeat PCI rate in patients with ischemic heart failure who underwent PCI for acute myocardial infarction.

AB - We prospectively followed 202 patients with ischemic heart failure who underwent percutaneous coronary intervention (PCI) for acute myocardial infarction (left ventricular [LV] ejection fraction <40%). Patients were divided into 2 groups: groups I (simvastatin group, n = 106, aged 60.8 ± 10.3 years, men 71.7%) and II (non-simvastatin group, n = 96, aged 60.9 ± 10.4 years, men 78.1%). During 1-year clinical follow-up, simvastatin therapy was associated with a significant reduction in mortality (1.9% vs 7.5%, p = 0.048), restenosis rate (25.7% vs 43.1%, p = 0.033), and repeat PCI rate (25.7% vs 43.1%, p = 0.033), and with significant improvement in LV ejection fraction (31% to 42% vs 32% to 39%, p = 0.042). The event-free survival rate was higher in group I than in group II (79.8% vs 57.0%, p = 0.001). In conclusion, simvastatin therapy improves LV systolic function and decreases mortality, restenosis, and repeat PCI rate in patients with ischemic heart failure who underwent PCI for acute myocardial infarction.

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Prognostic significance of simvastatin therapy in patients with ischemic heart failure who underwent percutaneous coronary intervention for acute myocardial infarction

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