TY - JOUR
T1 - Prognostic value of metabolic tumor volume measured by FDG-PET/CT in patients with cervical cancer
AU - Chung, Hyun Hoon
AU - Kim, Jae Weon
AU - Han, Kyung Hee
AU - Eo, Jae Seon
AU - Kang, Keon Wook
AU - Park, Noh Hyun
AU - Song, Yong Sang
AU - Chung, June Key
AU - Kang, Soon Beom
PY - 2011/2
Y1 - 2011/2
N2 - Objective: To determine if preoperative metabolic tumor volume (MTV) measured by integrated 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) imaging has prognostic value in patients with cervical cancer treated primarily with radical hysterectomy. Methods: Patients with FIGO stage IB to IIA cervical cancer were imaged with FDG-PET/CT before radical surgery. MTV was measured from attenuation-corrected FDG-PET/CT images using a standard uptake value (SUV)-based automated contouring program. We evaluated the relationship of MTV to disease-free survival (DFS). Results: A total of 63 patients were included in the study. The cut-off value for predicting recurrence was determined using a receiver operating characteristic (ROC) curve. MTV in this study was found to be correlated with lymph node (LN) metastasis, parametrium (PM) involvement, FIGO stage, and SUVmax. In univariate analysis, MTV ≥ 23.4 mL (HR 1.017, 95% confidence interval (CI) 1.005-1.029, P = 0.004), SUVmax ≥ 9.5 (HR 5.198, 95% CI 1.076-25.118, P = 0.04), LN metastasis (HR 12.338, 95% CI 1.541-98.813, P = 0.018), PM involvement (HR 14.274, 95% CI 1.785-114.149, P = 0.012), and lymphovascular space invasion (HR 8.871, 95% CI 1.104-71.261, P = 0.04), were related to DFS. In multivariate analyses, age (HR 0.748, 95% CI 0.587-0.952, P = 0.018) and MTV ≥ 23.4 mL (HR 49.559, 95% CI 1.257-1953.399, P = 0.037) were determined to be independent prognostic factors of DFS. Conclusion: Preoperative MTV is an independent prognostic factor for DFS in patients with cervical cancer treated by radical surgery.
AB - Objective: To determine if preoperative metabolic tumor volume (MTV) measured by integrated 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (FDG-PET/CT) imaging has prognostic value in patients with cervical cancer treated primarily with radical hysterectomy. Methods: Patients with FIGO stage IB to IIA cervical cancer were imaged with FDG-PET/CT before radical surgery. MTV was measured from attenuation-corrected FDG-PET/CT images using a standard uptake value (SUV)-based automated contouring program. We evaluated the relationship of MTV to disease-free survival (DFS). Results: A total of 63 patients were included in the study. The cut-off value for predicting recurrence was determined using a receiver operating characteristic (ROC) curve. MTV in this study was found to be correlated with lymph node (LN) metastasis, parametrium (PM) involvement, FIGO stage, and SUVmax. In univariate analysis, MTV ≥ 23.4 mL (HR 1.017, 95% confidence interval (CI) 1.005-1.029, P = 0.004), SUVmax ≥ 9.5 (HR 5.198, 95% CI 1.076-25.118, P = 0.04), LN metastasis (HR 12.338, 95% CI 1.541-98.813, P = 0.018), PM involvement (HR 14.274, 95% CI 1.785-114.149, P = 0.012), and lymphovascular space invasion (HR 8.871, 95% CI 1.104-71.261, P = 0.04), were related to DFS. In multivariate analyses, age (HR 0.748, 95% CI 0.587-0.952, P = 0.018) and MTV ≥ 23.4 mL (HR 49.559, 95% CI 1.257-1953.399, P = 0.037) were determined to be independent prognostic factors of DFS. Conclusion: Preoperative MTV is an independent prognostic factor for DFS in patients with cervical cancer treated by radical surgery.
KW - Cervical cancer
KW - Metabolic tumor volume
KW - PET/CT
KW - Recurrence
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=79251601258&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2010.11.002
DO - 10.1016/j.ygyno.2010.11.002
M3 - Article
C2 - 21109300
AN - SCOPUS:79251601258
SN - 0090-8258
VL - 120
SP - 270
EP - 274
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -
