PROM1-mediated cell signal transduction in cancer stem cells and hepatocytes

Myeong Suk Bahn, Young Gyu Ko

Research output: Contribution to journalArticlepeer-review

Abstract

Prominin-1 (PROM1), also called CD133, is a penta-span transmembrane protein that is localized in membrane protrusions, such as microvilli and filopodia. It is known to be expressed in cancer stem cells and various progenitor cells of bone marrow, liver, kidney, and intestine. Accumulating evidence has revealed that PROM1 has multiple functions in various organs, such as eye, tooth, peripheral nerve, and liver, associating with various molecular protein partners. PROM1 regulates PKA-induced gluconeogenesis, TGFβ-induced fibrosis, and IL-6-induced regeneration in the liver, associating with Radixin, SMAD7, and GP130, respectively. In addition, PROM1 is necessary to maintain cancer stem cell properties by activating PI3K and β-Catenin. PROM1-deficienct mice also show distinct phenotypes in eyes, brain, peripheral nerves, and tooth. Here, we discuss recent findings of PROM1-mediated signal transduction.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalBMB reports
Volume56
Issue number2
DOIs
Publication statusPublished - 2023

Bibliographical note

Funding Information:
We thank all members of our laboratory for their supports and intellectual inputs during the preparation of this manuscript. Funding: This work was supported by grants from the National Research Foundation of Korea awarded to; Y.-G. Ko (R1A5A1009024 and R1A2C1011601).

Publisher Copyright:
© 2023 by the The Korean Society for Biochemistry and Molecular Biology

Keywords

  • AKT
  • CD133
  • Cancer stem cell
  • GP130
  • HDAC6
  • Hepatocyte
  • IL-6
  • Lipid raft
  • Liver
  • Membrane protrusion
  • PI3K
  • PKA
  • PROM1
  • Prominin-1
  • Radixin
  • SMAD7
  • TGF-β
  • β-Catenin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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