TY - JOUR
T1 - Properties of fluoridated hydroxyapatite-alumina biological composites densified with addition of CaF2
AU - Kim, Hae Won
AU - Koh, Young Hag
AU - Seo, Seung Beom
AU - Kim, Hyoun Ee
N1 - Funding Information:
This work was supported by a grant of the Korea Health 21 R & D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/6/10
Y1 - 2003/6/10
N2 - Hydroxyapatite [HA, Ca10(PO4)6(OH) 2] composites with 20 vol.% alumina (Al2O 3) were sintered without pressure by adding CaF2. In the CaF2-free composites, severe decompositions occurred, resulting in poor densification. However, the addition of CaF2 suppressed the decomposition completely through the substitution of F- for OH- and consequent formation of fluor-hydroxyapatite [FHA, Ca10(PO4)6 (OH)2-2xF2x]-Al2O3 composite. Hence, the obtained bodies reached full densification possessing enhanced mechanical properties. The hardness, flexural strength and fracture toughness of the CaF2-added composites improved by factors of ∼ 2-3 compared to CaF2-free composites, having values of 8 GPa, 125 MPa and 1.2 MPa m1/2, respectively. The osteoblast-like cells showed a similar proliferation behavior with respect to pure HA and plastic control for up to 7 days. The alkaline phosphatase (ALP) activity of the proliferated cells on the composites was higher than that on plastic control and slightly lower than that on pure HA, especially after prolonged culture periods.
AB - Hydroxyapatite [HA, Ca10(PO4)6(OH) 2] composites with 20 vol.% alumina (Al2O 3) were sintered without pressure by adding CaF2. In the CaF2-free composites, severe decompositions occurred, resulting in poor densification. However, the addition of CaF2 suppressed the decomposition completely through the substitution of F- for OH- and consequent formation of fluor-hydroxyapatite [FHA, Ca10(PO4)6 (OH)2-2xF2x]-Al2O3 composite. Hence, the obtained bodies reached full densification possessing enhanced mechanical properties. The hardness, flexural strength and fracture toughness of the CaF2-added composites improved by factors of ∼ 2-3 compared to CaF2-free composites, having values of 8 GPa, 125 MPa and 1.2 MPa m1/2, respectively. The osteoblast-like cells showed a similar proliferation behavior with respect to pure HA and plastic control for up to 7 days. The alkaline phosphatase (ALP) activity of the proliferated cells on the composites was higher than that on plastic control and slightly lower than that on pure HA, especially after prolonged culture periods.
KW - CaF addition
KW - Cell response
KW - Hydroxyapatite-alumina composites
KW - Mechanical properties
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U2 - 10.1016/S0928-4931(02)00355-7
DO - 10.1016/S0928-4931(02)00355-7
M3 - Article
AN - SCOPUS:0038118497
SN - 0928-4931
VL - 23
SP - 515
EP - 521
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
IS - 4
ER -