Properties of fluoridated hydroxyapatite-alumina biological composites densified with addition of CaF2

Hae Won Kim; Young Hag Koh; Seung Beom Seo; Hyoun Ee Kim

doi:10.1016/S0928-4931(02)00355-7

Properties of fluoridated hydroxyapatite-alumina biological composites densified with addition of CaF₂

Hae Won Kim
, Young Hag Koh
, Seung Beom Seo
, Hyoun Ee Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Hydroxyapatite [HA, Ca₁₀(PO₄)₆(OH) ₂] composites with 20 vol.% alumina (Al₂O ₃) were sintered without pressure by adding CaF₂. In the CaF₂-free composites, severe decompositions occurred, resulting in poor densification. However, the addition of CaF₂ suppressed the decomposition completely through the substitution of F^- for OH^- and consequent formation of fluor-hydroxyapatite [FHA, Ca₁₀(PO₄)₆ (OH)_2-2xF_2x]-Al₂O₃ composite. Hence, the obtained bodies reached full densification possessing enhanced mechanical properties. The hardness, flexural strength and fracture toughness of the CaF₂-added composites improved by factors of ∼ 2-3 compared to CaF₂-free composites, having values of 8 GPa, 125 MPa and 1.2 MPa m^1/2, respectively. The osteoblast-like cells showed a similar proliferation behavior with respect to pure HA and plastic control for up to 7 days. The alkaline phosphatase (ALP) activity of the proliferated cells on the composites was higher than that on plastic control and slightly lower than that on pure HA, especially after prolonged culture periods.

Original language	English
Pages (from-to)	515-521
Number of pages	7
Journal	Materials Science and Engineering C
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/S0928-4931(02)00355-7
Publication status	Published - 2003 Jun 10
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a grant of the Korea Health 21 R & D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002).

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

CaF addition
Cell response
Hydroxyapatite-alumina composites
Mechanical properties

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1016/S0928-4931(02)00355-7

Cite this

@article{759b0b6e745a42c7bd054b2c1edda75e,

title = "Properties of fluoridated hydroxyapatite-alumina biological composites densified with addition of CaF2",

abstract = "Hydroxyapatite [HA, Ca10(PO4)6(OH) 2] composites with 20 vol.\% alumina (Al2O 3) were sintered without pressure by adding CaF2. In the CaF2-free composites, severe decompositions occurred, resulting in poor densification. However, the addition of CaF2 suppressed the decomposition completely through the substitution of F- for OH- and consequent formation of fluor-hydroxyapatite [FHA, Ca10(PO4)6 (OH)2-2xF2x]-Al2O3 composite. Hence, the obtained bodies reached full densification possessing enhanced mechanical properties. The hardness, flexural strength and fracture toughness of the CaF2-added composites improved by factors of ∼ 2-3 compared to CaF2-free composites, having values of 8 GPa, 125 MPa and 1.2 MPa m1/2, respectively. The osteoblast-like cells showed a similar proliferation behavior with respect to pure HA and plastic control for up to 7 days. The alkaline phosphatase (ALP) activity of the proliferated cells on the composites was higher than that on plastic control and slightly lower than that on pure HA, especially after prolonged culture periods.",

keywords = "CaF addition, Cell response, Hydroxyapatite-alumina composites, Mechanical properties",

author = "Kim, \{Hae Won\} and Koh, \{Young Hag\} and Seo, \{Seung Beom\} and Kim, \{Hyoun Ee\}",

note = "Funding Information: This work was supported by a grant of the Korea Health 21 R \& D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2003",

month = jun,

day = "10",

doi = "10.1016/S0928-4931(02)00355-7",

language = "English",

volume = "23",

pages = "515--521",

journal = "Materials Science and Engineering C",

issn = "0928-4931",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Properties of fluoridated hydroxyapatite-alumina biological composites densified with addition of CaF2

AU - Kim, Hae Won

AU - Koh, Young Hag

AU - Seo, Seung Beom

AU - Kim, Hyoun Ee

N1 - Funding Information: This work was supported by a grant of the Korea Health 21 R & D Project, Ministry of Health and Welfare, Republic of Korea (02-PJ3-PG6-EV11-0002). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2003/6/10

Y1 - 2003/6/10

N2 - Hydroxyapatite [HA, Ca10(PO4)6(OH) 2] composites with 20 vol.% alumina (Al2O 3) were sintered without pressure by adding CaF2. In the CaF2-free composites, severe decompositions occurred, resulting in poor densification. However, the addition of CaF2 suppressed the decomposition completely through the substitution of F- for OH- and consequent formation of fluor-hydroxyapatite [FHA, Ca10(PO4)6 (OH)2-2xF2x]-Al2O3 composite. Hence, the obtained bodies reached full densification possessing enhanced mechanical properties. The hardness, flexural strength and fracture toughness of the CaF2-added composites improved by factors of ∼ 2-3 compared to CaF2-free composites, having values of 8 GPa, 125 MPa and 1.2 MPa m1/2, respectively. The osteoblast-like cells showed a similar proliferation behavior with respect to pure HA and plastic control for up to 7 days. The alkaline phosphatase (ALP) activity of the proliferated cells on the composites was higher than that on plastic control and slightly lower than that on pure HA, especially after prolonged culture periods.

AB - Hydroxyapatite [HA, Ca10(PO4)6(OH) 2] composites with 20 vol.% alumina (Al2O 3) were sintered without pressure by adding CaF2. In the CaF2-free composites, severe decompositions occurred, resulting in poor densification. However, the addition of CaF2 suppressed the decomposition completely through the substitution of F- for OH- and consequent formation of fluor-hydroxyapatite [FHA, Ca10(PO4)6 (OH)2-2xF2x]-Al2O3 composite. Hence, the obtained bodies reached full densification possessing enhanced mechanical properties. The hardness, flexural strength and fracture toughness of the CaF2-added composites improved by factors of ∼ 2-3 compared to CaF2-free composites, having values of 8 GPa, 125 MPa and 1.2 MPa m1/2, respectively. The osteoblast-like cells showed a similar proliferation behavior with respect to pure HA and plastic control for up to 7 days. The alkaline phosphatase (ALP) activity of the proliferated cells on the composites was higher than that on plastic control and slightly lower than that on pure HA, especially after prolonged culture periods.

KW - CaF addition

KW - Cell response

KW - Hydroxyapatite-alumina composites

KW - Mechanical properties

UR - https://www.scopus.com/pages/publications/0038118497

UR - https://www.scopus.com/pages/publications/0038118497#tab=citedBy

U2 - 10.1016/S0928-4931(02)00355-7

DO - 10.1016/S0928-4931(02)00355-7

M3 - Article

AN - SCOPUS:0038118497

SN - 0928-4931

VL - 23

SP - 515

EP - 521

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

IS - 4

ER -