TY - JOUR
T1 - Proposal for genetic characterisation of wild-type mumps strains
T2 - Preliminary standardisation of the nomenclature
AU - Jin, L.
AU - Rima, B.
AU - Brown, D.
AU - Örvell, C.
AU - Tecle, T.
AU - Afzal, M.
AU - Uchida, K.
AU - Nakayama, T.
AU - Song, J. W.
AU - Kang, C.
AU - Rota, P. A.
AU - Xu, W.
AU - Featherstone, D.
PY - 2005/8
Y1 - 2005/8
N2 - Though mumps virus (MuV) is a monotypic virus, genetic variation between strains has been described. Viruses have been placed into genotypes designated A-L based on the nucleotide sequence of the small hydrophobic (SH) gene, which is the most variable gene in the mumps genome. Molecular characterisation of MuV is an important component of mumps surveillance because it can help identify the transmission pathways of the virus as well as distinguish between wild-type and vaccine strains. Here, we propose a standardized nomenclature and an analysis protocol for the genetic characterisation of mumps strains to facilitate expansion of molecular epidemiological studies. In addition to assigning standard reference strains for the recognized genotypes of MuV, a convention is proposed for naming for strains and criteria to designate a new genotype.
AB - Though mumps virus (MuV) is a monotypic virus, genetic variation between strains has been described. Viruses have been placed into genotypes designated A-L based on the nucleotide sequence of the small hydrophobic (SH) gene, which is the most variable gene in the mumps genome. Molecular characterisation of MuV is an important component of mumps surveillance because it can help identify the transmission pathways of the virus as well as distinguish between wild-type and vaccine strains. Here, we propose a standardized nomenclature and an analysis protocol for the genetic characterisation of mumps strains to facilitate expansion of molecular epidemiological studies. In addition to assigning standard reference strains for the recognized genotypes of MuV, a convention is proposed for naming for strains and criteria to designate a new genotype.
UR - http://www.scopus.com/inward/record.url?scp=23844545837&partnerID=8YFLogxK
U2 - 10.1007/s00705-005-0563-4
DO - 10.1007/s00705-005-0563-4
M3 - Article
C2 - 15959834
AN - SCOPUS:23844545837
SN - 0304-8608
VL - 150
SP - 1903
EP - 1909
JO - Archives of virology
JF - Archives of virology
IS - 9
ER -
