Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity

Hyun Seuk Moon; Hong Gu Lee; Yun Jaie Choi; Tae Gyu Kim; Chong Su Cho

doi:10.1016/j.cbi.2007.02.008

Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity

Hyun Seuk Moon, Hong Gu Lee, Yun Jaie Choi, Tae Gyu Kim, Chong Su Cho

Division of Biotechnology

Research output: Contribution to journal › Review article › peer-review

142 Citations (Scopus)

Abstract

Green tea catechins (GTCs) are polyphenolic flavonoids formerly called vitamin P. GTCs, especially (-)-epigallocatechin-3-gallate (EGCG), lower the incidence of cancers, collagen-induced arthritis, oxidative stress-induced neurodegenerative diseases, and streptozotocin-induced diabetes. Also, inhibition of adipogenesis by green tea and green tea extract has been demonstrated in cell lines, animal models, and humans. The obesity-preventive effects of green tea and its main constituent EGCG are widely supported by results from epidemiological, cell culture, animal, and clinical studies in the last decade. Studies with adipocyte cell lines and animal models have demonstrated that EGCG inhibits extracellular signal-related kinases (ERK), activates AMP-activated protein kinase (AMPK), modulates adipocyte marker proteins, and down-regulates lipogenic enzymes as well as other potential targets. Also, the catechin components of green tea have been shown to possess anti-carcinogenic properties possibly related to their anti-oxidant activity. In addition, it was shown that dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes mellitus. In this review, the biological activities and multiple mechanisms of EGCG in cell lines, animal models, and clinical observations are explained.

Original language	English
Pages (from-to)	85-98
Number of pages	14
Journal	Chemico-Biological Interactions
Volume	167
Issue number	2
DOIs	https://doi.org/10.1016/j.cbi.2007.02.008
Publication status	Published - 2007 Apr 25

Bibliographical note

Funding Information:
This work was supported by the Agricultural R&D Promotion Center (ARPC) (2006-0053). We also thank the National Instrumentation Center for Environmental Management (NICEM) for technical assistance. Hyun-Seuk Moon was supported by Brain Korea 21 (BK21) grant.

Keywords

(-)-Epigallocatechin-3-gallate
Anti-adipogenic mechanism
Clinical application

ASJC Scopus subject areas

Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cbi.2007.02.008

Cite this

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title = "Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity",

abstract = "Green tea catechins (GTCs) are polyphenolic flavonoids formerly called vitamin P. GTCs, especially (-)-epigallocatechin-3-gallate (EGCG), lower the incidence of cancers, collagen-induced arthritis, oxidative stress-induced neurodegenerative diseases, and streptozotocin-induced diabetes. Also, inhibition of adipogenesis by green tea and green tea extract has been demonstrated in cell lines, animal models, and humans. The obesity-preventive effects of green tea and its main constituent EGCG are widely supported by results from epidemiological, cell culture, animal, and clinical studies in the last decade. Studies with adipocyte cell lines and animal models have demonstrated that EGCG inhibits extracellular signal-related kinases (ERK), activates AMP-activated protein kinase (AMPK), modulates adipocyte marker proteins, and down-regulates lipogenic enzymes as well as other potential targets. Also, the catechin components of green tea have been shown to possess anti-carcinogenic properties possibly related to their anti-oxidant activity. In addition, it was shown that dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes mellitus. In this review, the biological activities and multiple mechanisms of EGCG in cell lines, animal models, and clinical observations are explained.",

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note = "Funding Information: This work was supported by the Agricultural R&D Promotion Center (ARPC) (2006-0053). We also thank the National Instrumentation Center for Environmental Management (NICEM) for technical assistance. Hyun-Seuk Moon was supported by Brain Korea 21 (BK21) grant.",

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AU - Kim, Tae Gyu

AU - Cho, Chong Su

N1 - Funding Information: This work was supported by the Agricultural R&D Promotion Center (ARPC) (2006-0053). We also thank the National Instrumentation Center for Environmental Management (NICEM) for technical assistance. Hyun-Seuk Moon was supported by Brain Korea 21 (BK21) grant.

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AB - Green tea catechins (GTCs) are polyphenolic flavonoids formerly called vitamin P. GTCs, especially (-)-epigallocatechin-3-gallate (EGCG), lower the incidence of cancers, collagen-induced arthritis, oxidative stress-induced neurodegenerative diseases, and streptozotocin-induced diabetes. Also, inhibition of adipogenesis by green tea and green tea extract has been demonstrated in cell lines, animal models, and humans. The obesity-preventive effects of green tea and its main constituent EGCG are widely supported by results from epidemiological, cell culture, animal, and clinical studies in the last decade. Studies with adipocyte cell lines and animal models have demonstrated that EGCG inhibits extracellular signal-related kinases (ERK), activates AMP-activated protein kinase (AMPK), modulates adipocyte marker proteins, and down-regulates lipogenic enzymes as well as other potential targets. Also, the catechin components of green tea have been shown to possess anti-carcinogenic properties possibly related to their anti-oxidant activity. In addition, it was shown that dietary supplementation with EGCG could potentially contribute to nutritional strategies for the prevention and treatment of type 2 diabetes mellitus. In this review, the biological activities and multiple mechanisms of EGCG in cell lines, animal models, and clinical observations are explained.

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Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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