Prospective investigation of change in the prostate-specific antigens after various urologic procedures

Seung Chol Park, Yu Seob Shin, Li Tao Zhang, Dal Sik Kim, Sung Zoo Kim, Nam Cheol Park, Tai Young Ahn, Je-Jong Kim, Sung Won Lee, Insuk So, Jong Kwan Park

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Scopus)


    Purpose: Prostate-specific antigen (PSA) is the most important marker in the diagnosis and follow-up of patients with prostate cancer. The primary objective of this study was to evaluate the effect of various urologic procedures in prostatic area on serum free and total PSA levels. Subjects and methods: A series of 62 patients (8 after digital rectal examination [DRE], 12 after transrectal ultrasonography [TRUS], 11 after rigid cystoscopy, 13 after prostatic massage, 8 after TRUS-guided prostate biopsy, and 10 after transurethral resection of prostate [TURP]) were enrolled in the study. Blood samples were taken from each patient before procedure and at 10, 30, 60, and 120 minutes after procedures. Results: Prostate massage, rigid cystoscopy, TURP, and TRUS-guided prostate biopsy caused statistically significant rise in total and free PSA levels in the serum. There was no significant increase in total and free PSA levels in the serum after DRE and TRUS. The mean differences were greater for free PSA level in the serum for TURP, TRUS-guided prostate biopsy, prostate massage, and rigid cystoscopy. Conclusion: Total and free PSA levels in the serum are altered by prostate massage, rigid cystoscopy, TRUS-guided prostate biopsy, and TURP. The PSA rises were related to the stimulation strength of the procedures. The total and free PSA levels were increased significantly from 10 minutes after procedures, except DRE and TRUS, and were increased to maximal level at 60 minutes after procedures.

    Original languageEnglish
    Pages (from-to)1213-1218
    Number of pages6
    JournalClinical Interventions in Aging
    Publication statusPublished - 2015 Jul 29


    • Diagnosis
    • Marker
    • Prostate cancer
    • Prostate specific antigen (PSA)
    • Urologic procedures

    ASJC Scopus subject areas

    • Geriatrics and Gerontology


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